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Rotator Cuff Tear clinical trials

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NCT ID: NCT03300531 Not yet recruiting - Rotator Cuff Tear Clinical Trials

Impact of Autologous Pure Platelet-rich Plasma in the Treatment of Tendon Disease

Start date: December 1, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized parallel controlled double-blind phase 2 clinical study.All subjects are recruited from the patients of rotator cuff tear, lateral epicondylitis or chronic achilles tendonitis. Patients will be randomly divided into three groups. Autologous pure platlet-rich plasma (P-PRP) and platlet-rich plasma (PRP) are purified from the peripheral blood .Patients of case groups will receive P-PRP or PRP injection once a week for three times while the control group received the same dose compound betamethasone injection. Follow up visit will occur at 1 month,3 months, 6 months,12 months after the last injection. Clinical quantitative assessment will measure by the visual analogue scale(VAS). The secondary outcomes are the constant-murley score(CMS) and the rating scale of the American shoulder and elbow surgeons(ASES) and the disability of arm shoulder and hand(DASH). The objective evaluation methods is that the examination of MRI or ultrasound were accomplished before the first injection and at 6 and 12 months afterwards.

NCT ID: NCT03295994 Recruiting - Rotator Cuff Tear Clinical Trials

Operative Versus Non-Operative Treatment for Atraumatic Rotator Cuff Tears

ARC
Start date: March 19, 2018
Phase: N/A
Study type: Interventional

Rotator cuff tears are one of the most common reasons to seek musculoskeletal care in the United States and one of the fastest growing ambulatory surgery procedures. However, data on comparison of operative versus non-operative treatment is lacking and urgently needed.

NCT ID: NCT03290196 Suspended - Rotator Cuff Tear Clinical Trials

The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics

Start date: September 3, 2015
Phase: Phase 4
Study type: Interventional

Patients undergoing shoulder rotator cuff surgery in an outpatient setting are the focus of this study. The purpose of this study is to determine if the product EXPAREL® can be used as a safe alternative in shoulder surgery to pain pumps, while limiting narcotic use and providing appropriate postoperative pain control.

NCT ID: NCT03279796 Not yet recruiting - Rotator Cuff Tear Clinical Trials

Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

This study was a single-center, randomized, single-blind clinical trial. We plan to include 100 patients who met exclusion criteria of rotator cuff and lateral epicondylosis (tennis elbow) respectively by MRT or ultrasonography. The patients will be randomly divided into two groups. Adipose mesenchymal stem cells will be isolated from adipose tissue, cultured and then transplanted back to the tendon injury site by multiple point injection. 1*10^6 cells as an unit. Patients in the experiment group will be injected into an unit of adipose mesenchymal stem cells (1*10^6/10kg) while the control group received the same dose compound betamethasone injection. Follow up visit for all patients will occur at 1,3,6 and 12 months after the first injection. Clinical quantitative assessment will measure by the visual analogue scale(VAS). The secondary outcomes are the constant-murley score(CMS) and the rating scale of the American shoulder and elbow surgeons(ASES) and the disability of arm shoulder and hand(DASH). The objective evaluation methods is that the examination of MRI or ultrasound were accomplished before the first injection and at 6 and 12 months afterwards.

NCT ID: NCT03199391 Completed - Rotator Cuff Tear Clinical Trials

BioWick SureLock Clinical Outcomes Study

Start date: April 26, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to collect postmarket data in subjects who receive surgical treatment of a full-thickness rotator cuff tear (of at least 1.5 cm) with the BioWick™ SureLock™ implant. Both performance and safety data will be collected.

NCT ID: NCT03149887 Completed - Rotator Cuff Tear Clinical Trials

Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair

Start date: December 5, 2017
Phase: Phase 4
Study type: Interventional

Liposomal bupivacaine, a long-acting form of bupivacaine, has been found to be effective for postoperative pain control after total knee, total hip and total shoulder arthroplasty. We are conducting a randomized, controlled trial to evaluate pain control after arthroscopic rotator cuff repair in ambulatory patients, comparing standard care in the control group, with standard care plus the addition of injection of liposomal bupivacaine in the experimental group.

NCT ID: NCT03091075 Active, not recruiting - Rotator Cuff Tear Clinical Trials

Oxandrolone Rotator Cuff Trial

ORCT
Start date: September 23, 2018
Phase: N/A
Study type: Interventional

This study is about healing after a rotator cuff tear repair procedure. We hope to learn if a biologic medication: Oxandrolone, a synthetic derivative of the human hormone Testosterone (the principal male sex hormone and an anabolic steroid), given for 12 weeks following rotator cuff repair, is effective in aiding in the healing process and restoring muscle mass.

NCT ID: NCT03073655 Completed - Rotator Cuff Tear Clinical Trials

The Effects of Kinesio Tape Application With Different Verbal Input Given to With Patients With Rotator Cuff Tear

Start date: January 2016
Phase: N/A
Study type: Interventional

The aim of the study to investigate the effectiveness KT application with different verbal inputs on pain, function and range of motion (ROM) on patient with rotator cuff tear.

NCT ID: NCT03068988 Active, not recruiting - Rotator Cuff Tear Clinical Trials

Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions

Start date: January 1, 2012
Phase: Phase 1
Study type: Interventional

The prospective randomized clinical study investigating the effect of mesenchymal stem cells on tendon healing. The objective of the study is to demonstrate the effect of concentrated bone marrow stem cells ( MSCs ) to the healing of sutured tendon of the supraspinatus muscle in comparison to the same procedure performed without MSCs. We have postulated the hypothesis that MSCs enhance the healing of the sutured supraspinatus tendon to its humeral footprint.

NCT ID: NCT03060928 Not yet recruiting - Rotator Cuff Tear Clinical Trials

Evaluation of Tendon-to-Bone Healing Potential in Arthroscopic Rotator Cuff Repair Through Biological Stimulation

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

Evaluation of clinical and radiological outcomes in patients undergoing Arthroscopic Rotator Cuff Repair with standard treatment compared to patients receiving biological stimulation with micro-perforations or with the combination of micro-perforations and use of Artelon® Tissue Reinforcement, a synthetic device based on degradable polyurethaneurea. The investigators believe that this kind of tendon-to-bone healing stimulation with the two proposed methods can increase the repair quality by significantly decreasing the lesion recurrence rate (currently described for 15% of patients) and can improve various parameters such as pain, range of motion and strength, thereby hastening the return to daily activities and psycho-physical well-being.