Rosacea Clinical Trial
Official title:
Investigation of PACAP38-induced Headache and Rosacea-like Symptoms in Patients With Rosacea
The investigators aim is to investigate the incidence of headache and rosacea-like flushing after pituitary adenylate cyclase-activating peptide-38 (PACAP38) with and without treatment with sumatriptan in patients with rosacea
Pituitary adenylate cyclase-activating peptide-38 (PACAP38) plays a role in rosacea
pathophysiology. Infusions of PACAP38 can trigger migraine-like attacks in migraine patients.
PACAP38 also induces flushing which may imitate rosacea-like flushing. We are investigating
whether the flushing after PACAP38 resembles rosacea-like flushing, and whether treatment
with sumatriptan has an effect on the headache and flushing effects of PACAP38.
The purpose of this study is to investigate PACAP38-induced headache and flushing in patients
with rosacea who have been treated with either sumatriptan or placebo using purpose-developed
standardized interview. The investigators will use a double-blind, placebo-controlled
crossover study design to investigate this.
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