Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Root Resorption Clinical Trial

Official title:

Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04410679
• Other study ID #: FayoumU
• Status: Completed
• Phase: N/A
• Start date: June 3, 2018
• Est. completion date: May 2, 2020

Study information

• Verified date: October 2021
• Source: Fayoum University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Description:

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: May 2, 2020
• Est. primary completion date: June 6, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 13 Years to 30 Years

Eligibility

Inclusion Criteria:

• patients 13-30 years old

• no sex predilection

• medically free

• Suffering from internal inflammatory root resorption in permanent anterior mature teeth

• associated with or without periapical radiolucency

• no or grade I tooth mobility, and a pocket depth <3 mm

Exclusion Criteria:

• old age

• Medically medically compromised patients

Related Conditions & MeSH terms

• Root Resorption

Intervention

Biological:
• injectable PRF
blood sample and centrifuged to obtain i-PRF

Locations

Country	Name	City	State
Egypt	Faculty of dentistry Fayoum University	Fayoum

Sponsors (1)

Lead Sponsor	Collaborator
Fayoum University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in volumetric size of internal root resorption lesions	Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT	12 months
Secondary	change in volumetric size of periapical lesions	Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT	12 months