Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound

Status Unknown status

Clinical Trial Summary

Tooth-root resorption, also known as shortening or erosion,(TRR) is one of the adverse outcomes of dental trauma, orthodontic tooth movement and dental replantation/transplantation. Orthodontically induced inflammatory root resorption (OIIRR) is somewhat different from other types of TRR. The treatment protocol of teeth diagnosed with severe OIIRR or other forms of TRR always involves root canal treatment or extraction of these teeth in severe cases and prosthetic replacement. Sometimes teeth with minor TRR may stay for an extended period of time with compromised bite functions. Although several trials have been proposed to minimize or prevent TRR or OIIRR, none is capable of being used in clinical situation to treat TRR or OIIRR in humans except for Low Intensity Pulsed Ultrasound (LIPUS). However, research examining the use of LIPUS to treat OIIRR has been limited to simple orthodontic tooth tipping. In reality, tooth movement is a combination of different types of tooth movements, namely tipping, bodily, rotational, torque, intrusion and extrusion tooth movements. However, the literature have pointed out that torque tooth movement, especially when the root apices are torques against cortical plates of bone produces the most dramatic type of tooth root resorption with poor prognosis. Our long-term goal is to develop a standard protocol for treating severe tooth root resorption with poor prognosis in humans, regardless of origin. Our preliminary data demonstrates that LIPUS can produce healing of OIIRR in humans after simple tipping movement, this was confirmed by an in-vitro study on isolated cementoblasts. The objective of the present proposal is to evaluate the effect of different treatment protocols of LIPUS on the healing process of orthodontically induced tooth-root resorption due to torque (Complex)type of tooth movement in humans.

The study Hypotheses are (I) LIPUS treatment for 20 minutes per day for 4 weeks will be effective in repairing OIIRR due to torque tooth movement.

(II) The stimulatory effect of LIPUS to repair OIIRR due to torque tooth movement than LIPUS treatment is dose and time dependent.

Clinical Trial Description

For each patient, specially designed springs will be used to achieve standard torque orthodontic tooth movement of the first premolars to induce OIIRR. The first molars will be stabilized, using a special appliance to help movement of the premolars. This type of appliance design has been used for many years in similar clinical trials by many researchers and has received wide acceptability without reported problems to the teeth during the experimental period. Ultrasound will be applied for twenty minutes per day, starting the day the springs are activated, for four weeks, using an ultrasound device (Exogen Inc., West Caldwell, NJ, USA). Only the first premolar will be receiving ultrasound. The patients will be instructed on how to have the ultrasound transducer. The non LIPUS treated premolars will be receiving sham transducers. A visual analogue scale will be provided to the patients to record any pain or discomfort that the patient might experience during or after application of ultrasound. It is expected that there will be no evidence of any deleterious effect on the intervening soft tissue as we did not informed with any discomfort experienced by the patients in our preliminary study. After four or eight weeks of LIPUS treatment, the springs will be removed, and the first premolars will be extracted, using a non-traumatic technique. The extracted teeth will be fixed, and studied by μ-CT then they will be processed to be analyzed histomorphometrically ;

Study Design

Related Conditions & MeSH terms

Root Resorption

Clinical Trial Details

NCT number	NCT00423956
Study type	Interventional
Source	University of Alberta, Graduate Orthodontic Program
Contact	Dr. Tarek H El-Bialy, PhD
Phone	1-780-492-2751
Email	telbialy@ualberta.ca
Status	Unknown status
Phase	Phase 1/Phase 2
Start date	January 2007
Completion date	December 2015

View Details

See also
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Completed	`NCT03613285` - A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets	N/A
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Completed	`NCT04825665` - The Effect of Two Different Types of Forces on Possible Root Resorption in Relation to Dentin Phosphoprotein Levels	N/A
Completed	`NCT04291443` - Proteomics and Orthodontic Root Resorption	N/A
Completed	`NCT04410679` - Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque	N/A
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Completed	`NCT02822040` - An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs	N/A
Completed	`NCT04823325` - Determining the Presence of RAP in Orthognathic Patients and Its Effect on Root Resorption by Biomarkers
Recruiting	`NCT06199674` - Effects of PBM on Fixed-appliance Orthodontic Patients	N/A
Active, not recruiting	`NCT05606185` - Amount of Root Resorption of Maxillary Anteriors After en Masse Versus Two Step Space Closure	N/A
Recruiting	`NCT05232318` - Root Resorption Accompanied Clear Aligners and Fixed Orthodontic Appliance	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.