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Clinical Trial Summary

This is an observational study aiming to prospectively define the rate of occurrence, natural history and progression of cardiac dysfunction in adults, and to identify the patients at high risk of developing cardiovascular events. The study enrolls patients prior to infusion with CART cell therapy and follows them with serial echocardiography, cardiac biomarkers, clinical data, and quality of life questionnaire.


Clinical Trial Description

Patients have echo, blood draw, and QoL survey prior to CART infusion, then 2 days, 1 week, 1 month and 6 months following CART infusion. If patients experiences CRS, study team acquires echo within 72 hours of onset. As part of an optional substudy, patients wear an event monitor for 10 days, starting day of CART infusion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04026737
Study type Observational [Patient Registry]
Source Abramson Cancer Center of the University of Pennsylvania
Contact
Status Completed
Phase
Start date July 22, 2019
Completion date November 16, 2022

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