Right Ventricular Dysfunction Clinical Trial
Official title:
Early Peri-operative Right Ventricle Dysfunction Following Major Lung Resection
Major lung resection is associated with high post-operative morbidity and mortality and
significant long-term decreased functional capacity, especially due to cardiorespiratory
complications.
RV (Right Ventricle) ejection, pulmonary artery pressure and tone are tightly coupled. The RV
is exquisitely sensitive to changes in afterload. When pulmonary vascular reserve is
compromised RV ejection may be also compromised, increasing right atrial pressure and
limiting maximal cardiac output. Acute increase in RV outflow resistance, as may occur with
acute pulmonary embolism will cause acute RV dilatation and, by ventricular interdependence,
markedly decreased LV (Left Ventricle) compliance, rapidly spiraling to acute cardiogenic
shock and death.
Most of the studies on RV function after lung resection are small and have found different
results, and sometimes conflicting findings. As far as the investigators know, there are no
data on the incidence of the RV dysfunction after major lung resection
(pneumonectomy/bilobectomy) and it's not clear if there is some direct association between
the RV dysfunction and post-operative complications. If so, early detection of RV dysfunction
after major lung resection could provide the opportunity for interventional therapy with
consequent possible improvement of these patients' prognosis.
The aim of this study is to identify the incidence of early RV systolic dysfunction (defined as Tricuspid Annular Plane Systolic Excursion (TAPSE) < 17 cm, S' (TDI) < 10 cm/s) and estimate the RV-PA (Right Ventricle-Pulmonary Artery) coupling as indicated by Guazzi et all. (TAPSE/PAPs ratio, where PAPs is the Systolic Pulmonary Artery Pressure) after major lung resection (bilobectomy and pneumonectomy) using echocardiography, and to assess if these modifications (RV dysfunction and RV-PA coupling) may be associated with post-operative cardiopulmonary complications occurring during the hospitalization period. Investigators also intend to evaluate if these changes are associated with impaired functional capacity at 3 months after surgery. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03183414 -
Right Ventricular Dysfunction in Cardiac Surgery Patients
|
||
| Recruiting |
NCT04764032 -
Right Ventricular Dysfunction in Ventilated Patients With COVID-19
|
||
| Not yet recruiting |
NCT05188222 -
Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery
|
Phase 4 | |
| Not yet recruiting |
NCT06002321 -
Right Ventricular Dysfunction in Chronic Heart Failure
|
||
| Completed |
NCT05948332 -
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
|
||
| Recruiting |
NCT03309852 -
Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient
|
||
| Recruiting |
NCT05583461 -
Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS
|
N/A | |
| Completed |
NCT03438825 -
PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients
|
||
| Active, not recruiting |
NCT01230294 -
New Echocardiographic Methods for Right Ventricular Function.
|
N/A | |
| Completed |
NCT00557934 -
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
|
N/A | |
| Completed |
NCT04694378 -
Relationship Between Strain and Stroke Volume in Cardiac Surgery
|
||
| Recruiting |
NCT03013075 -
General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function
|
Phase 4 | |
| Completed |
NCT06197256 -
Cardiac Dysfunction in Critically Ill Covid-19 Patients
|
||
| Completed |
NCT03301571 -
Right Ventricular Echocardiography in caRdiac SurgEry
|
N/A | |
| Recruiting |
NCT05860504 -
Acute Cardiac Dysfunction in Critical Illnes
|
||
| Completed |
NCT01093001 -
Tricuspid Regurgitation Study
|
Phase 4 | |
| Recruiting |
NCT05758194 -
Mitigating Post-Op RV Dysfunction After LVAD Implantation
|
N/A | |
| Not yet recruiting |
NCT05768230 -
Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MV
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT05620992 -
Evaluation of Right Ventricular Function Post Mitral Valve Operations
|
||
| Completed |
NCT03806582 -
Effect of a Higher Blood-pressure on Right Ventricular Function
|
Phase 4 |