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Clinical Trial Summary

Post extraction alveolar bone resorption is one of the main challenges that face oral implantologists in their daily surgical practice (1). To palliate to post-extraction resorption, advanced bone grafting and regeneration techniques have been described (2). However, these procedures, although well documented and validated, still have relatively high complication rates and patient morbidity, in addition to the elevated cost and duration of treatment (3). Socket preservation is a very useful technique in order to counter post extraction resorption issues, therefore eliminating the need for future complicated and delicate regeneration procedures (4). Many biomaterials were proposed for socket preservation such as allografts and bovine hydroxyapatite (5). Recently autologous platelet concentrates such as Platelet Rich Fibrin PRF were described as a potential socket filler material (6). In the proposed protocol, fresh extraction sockets will be either grafted by a bovine bone substitute, a PRF plug or a mixture of both. Sockets will then be clinically and radiographically monitored over time to assess three-dimensional soft and hard tissue stability. Bone quality will be histologically examined at 6 months implant placement. A no graft group will serve as control. The results of this study may be of major importance since they could give an objective idea of the most efficient socket preservation technique, thus offering simple and secure oral rehabilitation solutions for both patient and practitioner.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05889377
Study type Interventional
Source Saint-Joseph University
Contact
Status Enrolling by invitation
Phase N/A
Start date November 3, 2021
Completion date December 20, 2024

See also
  Status Clinical Trial Phase
Completed NCT03205800 - Temporary Anchorage Devices for Ridge Preservation N/A
Completed NCT03497403 - Socket Preservation Procedure Studying Soft and Hard Tissue Outcomes N/A
Active, not recruiting NCT05437172 - Evaluation of Autogenous Demineralized Dentin Graft for Ridge Preservation With and Without Injectable Platelet Rich Fibrin N/A
Active, not recruiting NCT04133363 - To Compare Ridge Preservation Technique Using Leukocyte Platelet Rich Fibrin (L-PRF) and Freeze-dried Bone Allograft (FDBA) Layered Technique vs L-PRF/FDBA and L-PRF Alone in Influencing Quantity and Quality of New Bone Formation in Grafted Extraction Sockets N/A
Active, not recruiting NCT04329351 - Impact of PTFE-d Barrier Intentionally Exposed to Bucal Environment in Guided Bone Regeneration to Ridge Preservation N/A
Completed NCT02152215 - Ridge Preservation Comparing a Polylactic Acid Membrane vs. an Acellular Dermal Matrix Membrane Phase 4
Completed NCT03268512 - Effect of L-PRF and A-PRF in Ridge Preservation N/A