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Richter's Transformation clinical trials

View clinical trials related to Richter's Transformation.

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NCT ID: NCT01217749 Completed - Clinical trials for Small Lymphocytic Lymphoma

Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLL

PCYC-1109-CA
Start date: December 2010
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of a fixed-dose, daily regimen of orally administered PCI-32765 combined with ofatumumab in subjects with relapsed/refractory CLL/SLL and related diseases

NCT ID: NCT00472849 Completed - Leukemia Clinical Trials

Oxaliplatin, Fludarabine, Cytarabine, and Rituximab in Patients With Richter's Transformation and Leukemias

Start date: May 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this clinical research study is to find the highest tolerable dose of fludarabine and cytarabine that can be given in combination with oxaliplatin and rituximab in the treatment of chronic lymphocytic leukemia (CLL), prolymphocytic leukemia, or Richter's transformation. Once the highest tolerable dose for this drug combination is found, the next goal of the study will be to find out if this combination therapy is effective in shrinking or slowing the growth of these diseases.