Betadine Effect on Nasal Mucosa Cilia

Status Withdrawn

Clinical Trial Summary

The goal of the proposed study is to identify PVP-I at 1.25% as an appropriate intranasal topical preparation for patients undergoing rhinoplasty with no effect on the nasal mucosa cilia (NMC) or olfaction using the saccharin transit time (STT) test as a method for evaluating NMC function. PVP-I has been shown to be viricidal in the upper aerodigestive tract. This study is highly-relevant, as protection for individuals with a high risk of exposure to respiratory pathogens has become increasingly important in the setting of recent viral epidemics such as SARS-CoV-2. Septorhinoplasty is commonly performed throughout the world and there is a paucity of standardized testing in surgical facilities. Much of our understanding of the current COVID-19 pandemic is extrapolated from MERS and SARS data. It is our hope that this study's relevance for the current pandemic remains so in the unfortunate event of another pandemic in the future.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Rhinoplasty

Clinical Trial Details

NCT number	NCT04457765
Study type	Interventional
Source	Boston Medical Center
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	April 2021
Completion date	September 2022

View Details

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