RHINOPLASTY Clinical Trial
Official title:
Chronic Rhinosinusitis Classification Proposal: Evaluation of the Severity and the Effectiveness of Medical and Surgical Treatments
Chronic rhinosinusitis (CRS) is a debilitating disease that remains (smell, nasal patency, flow) because currently treatment protocols available to us are with a limited efficacy. The assessment of the response to surgical treatment protocols and monitoring the become of patients treated with only drugs should allow investigators to identify the predictive patient's profile for the response. With this prospective data, this study would allow investigators to make a classification of Chronic rhinosinusitis.
Chronic rhinosinusitis (CRS) is a debilitating disease that remains (smell, nasal patency,
flow) because currently treatment protocols available to us are with a limited efficacy.
For many years, practitioners have tried to identify a universal therapeutic protocol. It
turns out that no treatment (functional endoscopic surgery, antifungal therapy, medical
treatment with antibiotics / corticosteroids) does not resolve all of the symptoms and their
effectiveness is variable from one patient to another.
The most plausible explanation is that the term "rhinosinusitis" includes various different
pathophysiological mechanism entities, requiring different treatment. Like certain skin or
lung diseases, chronic inflammation of the sinuses may have different origins, allergic or
extrinsic (infectious). It is therefore important to determine the type of inflammation
responsible for adapting the management.
First, it is important to determine from all forms of CRS (with or without polyps), those
associated with allergic inflammation and infectious ones. The presence or absence of polyps
does not appear to be a determining factor of the type of inflammation. However, the criteria
- allergy and asthma - could provide guidance to an allergic mechanism.
The study aims to distinguish different phenotypes CRS according to clinical, anatomical
criteria and biological criteria. Clinical classification obtained would assess and predict
more finely treatment response and target according to the phenotype, the best supported.
Surgery is one of the therapeutic options in the treatment of rhinosinusitis, but the term
satisfaction of healing and patient comfort is variable, a finer and precise distribution of
patients will allow us to better predict the success of the surgery and therefore the offer
targeted patients.
Primary objective :
To assess the response to surgical treatment of rhinosinusitis and the outcome of these
patients in order to highlight predictors of success of surgery.
Secondary objectives:
Assess chronic rhinosinusitis phenotype by score SNOT 22 (importance of symptoms) which
assesses the average severity of different groups Assessing the future of non-operated
patients
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