Rhinitis Clinical Trial
Official title:
Preventing Respiratory Health Problems in Bakery Employees.
The study is a follow-up of investigations done in the years 1999-2002 in bakery employees. The main purposes are to look at the associations between flour dust exposure and respiratory disease, and to find out the best ways to reduce the flour dust levels in the working environment.
Background and Methods:
Supported by the The Confederation of Norwegian Enterprise (CNBI) Working Environment Fund a
follow-up study of 184 bakery workers in 5 bakeries was done in 2012, appr. 10 years after a
similar study in 1999-2002. In addition a cross-sectional study in 2 other bakeries (one
'bread-factory', and a traditional bakery with three small bake shops) was added.
Altogether 253 participants, among them 61 former bakery workers, were investigated with use
of questionnaires, allergy-testing (skin prick testing, and blood samples for specific IgE
and total IgE), spirometry with reversibility testing, exhaled NO-measurement, and nasal
measurements.
As in 1999-2002 an extensive exposure assessment was performed including personal samples of
total dust (Gelman), inhalable dust (PAS6), as well as direct reading measurements of dust
(Dust Track). A Job Exposure Matrix (JEM) was created enabling each participant to be
assigned an exposure value of probable mean daily flour-dust exposure based on work-tasks and
bakery.
Aim of study:
- Follow-up of the participants in the 1999-2002 study, both still active bakery workers
and former workers, on health-status focusing on respiratory disease, sensitization to
common and occupational allergens, level of sick-leave and reasons for quitting as a
baker.
- Inclusion of 'new' bakery workers into the cohort as a cross-sectional study, and to
compare health-status in two cross-sectional cohorts.
- To assess personal exposure to flour-dust among workers in 7 bakeries, as part of the
cross-sectional study described above.
- To identify implemented flour-dust exposure reduction measures in bakeries participating
in 1999-2002, and to assess the potential impact of these measures on the exposure to
flour dust.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02360072 -
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma
|
||
| Completed |
NCT02340130 -
Safety, Tolerability and Efficacy of the Depigmented Modified Allergen Extract of Two Mites in Subjects With Allergic Rhinitis or Rhinoconjunctivitis, With Controlled Allergic Asthma
|
Phase 2 | |
| Completed |
NCT01118312 -
Study of Asthma and Nasal Steroids
|
Phase 4 | |
| Completed |
NCT00762567 -
Phenylephrine Pediatric Pharmacokinetic Study
|
Phase 1 | |
| Completed |
NCT00541255 -
A Long-Term Examination of Asthma From Childhood Through Adolescence
|
||
| Completed |
NCT00279916 -
Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays
|
Phase 3 | |
| Completed |
NCT00524836 -
Efficacy and Safety of Levocetirizine Versus Loratadine for the Treatment of Perennial Allergic Rhinitis
|
Phase 3 | |
| Completed |
NCT00963573 -
Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428)
|
Phase 4 | |
| Completed |
NCT00521131 -
Evaluation of Efficacy and Safety of Levocetirizine to Subjects With Perennial Allergic Rhinitis to House Dust Mites
|
Phase 4 | |
| Completed |
NCT04132570 -
A Study of Intranasal Budesonide Aqueous Spray for Treatment of Rhinitis During Periods of High Airborne Pollution
|
Phase 4 | |
| Completed |
NCT02784262 -
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis
|
Phase 2 | |
| Completed |
NCT02596321 -
A Study Investigating the Immunologic Effects and Safety of 60-day Treatment of the ALK HDM Tablets in Adult Subjects With HDM-Induced Allergic Rhinitis and/or Atopic Asthma
|
Phase 3 | |
| Terminated |
NCT02630472 -
Topical Irrigation Therapy for CRS
|
Phase 1/Phase 2 | |
| Completed |
NCT02279706 -
Korean Linguistic Adaptation of Rhinitis Controlled Assessment Test
|
N/A | |
| Completed |
NCT01971086 -
Treatment With Rhinospray Plus in Patients With Acute Rhinitis in the Everyday Curative Routine in Hungary
|
N/A | |
| Completed |
NCT01771120 -
Control and Burden of Asthma and Rhinitis
|
N/A | |
| Completed |
NCT01469234 -
A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712)
|
Phase 4 | |
| Withdrawn |
NCT01177852 -
Evaluation of Efficacy and Safety in Control Cough and the Relief of Nasal Symptoms in Children 2-12 Years Old,Suffering From Cough and Acute Rhinitis
|
Phase 3 | |
| Completed |
NCT02879929 -
Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction
|
N/A | |
| Completed |
NCT00724698 -
Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria
|