Mechanism of EGR2 in Allergic Rhinitis

Status Enrolling by invitation

Clinical Trial Summary

EGR2 may be a target for the treatment of nasal polyps.

Clinical Trial Description

There is much debate about the etiology of nasal polyps, so the pathogenesis of nasal polyps still needs to be clarified. Surgery for noninflammatory nasal polyps may be better control, but surgery is not effective for recurrent sinusitis and nasal polyps. Therefore, more research is needed to determine the best targeted therapy for nasal polyps. We found that EGR2 expression was upregulated in CRSwNP patients with allergic rhinitis.In addition, the expression of EGR2 in CRSwNP mucosa was significantly higher than that in the control group, and the expression of EGR2 in CRSwNP with allergic rhinitis was higher than that in CRSwNP without allergic rhinitis. EGR2 may be involved in the pathogenesis of nasal polyps, and may also be related to the severity and recurrence of nasal polyps. EGR2 may be a target for the treatment of nasal polyps. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05724290
Study type	Interventional
Source	Zunyi Medical College
Contact
Status	Enrolling by invitation
Phase	Phase 1
Start date	January 30, 2023
Completion date	May 5, 2023

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