Rhinitis, Allergic Clinical Trial
Official title:
The Oligonucleotide Chip Analysis for Allergic Rhinitis Treatment in Herbal Plaster and Acupuncture
Using Oligonucleotide Chip Analysis, investigators compared gene expression levels in
allergic rhinitis patients before and after a series of acupoint herbal plaster and
Acupuncture treatment.
In the first year, Twenty-three participants with persistent allergic rhinitis each received
four acupoint herbal plaster treatments, applied using the moxibustion technique, and
clinical outcomes were evaluated using the Rhinitis Quality of Life Questionnaire (RQLQ).
Peripheral blood samples were analyzed using an ImmunoCAP Phadiatop test, and patients were
classified as phadiatop (Ph)-positive or -negative. Microarray results were examined for
genes that were differentially expressed between (1) Ph-positive and -negative patients
treated with herbal paste; and (2) before and after herbal paste treatment in the
Ph-positive patient group.
In the second year, Twenty-seven participants with persistent allergic rhinitis each
received four acupoint herbal plaster treatments and 8 courses of acupuncture treatment over
4 weeks in the same time.
This project「The oligonucleotide chip analysis for allergic rhinitis treatment in herbal
plaster and acupuncture」 will be performed at Genomic Medicine Research Core Laboratory-
GMRCL in Chung Gang Memorial Hospital. Allergic rhinitis patient will receive herbal plaster
treatment in the first year, blood sample was attained before and after therapy. Then
investigators use oligonucleotide chip to analyze the immunomodulatory effects of TCM in the
treatment of allergic rhinitis. In the second year, the patient received herbal plaster and
Acupuncture treatment in the same time.
Many allergic rhinitis patients accept TCM treatment here in Taiwan. According to recent
journal reports, Traditional Chinese medicine performed in accordance with the principles of
TCM would show significant immune-modulating effects, herbal plaster is an effective, safe
and convenient treatment for allergic rhinitis. The mechanism of its efficacy needs further
study. This project plan to combine the experience of clinical doctor and GMRCL Microarray
for the mechanism of herbal plaster on allergic rhinitis.
Investigators study the effects of herbal plaster treatment for allergic rhinitis in the
first year. And study the combine effect of herbal plaster and Acupuncture treatment in the
second year. All patients during 18-45 years old were treated over a time period of 4 weeks.
Patients' general well-being and several peripheral blood parameters were determined before
and after the herbal plaster treatment. RNA was extracted from the blood and pooled into
patient pool. Oligonucleotide chips were used to analysis the pooled RNA each year. The
microarray analysis for the genomic change before and after the herbal plaster treatment or
herbal plaster with Acupuncture treatment was studied .
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