Rhinitis, Allergic, Seasonal Clinical Trial
Official title:
Optimal Concentration of Allergen Extract of Dermatophagoides Pteronyssinus to be Used in Diagnostic Allergy Skin Prick Test Among Thai Population
The purpose of this study is to determine the appropriate concentration of diagnostic reagent of house dust mite (Dp) to be used in diagnostic allergy skin prick test among Thai population with allergic rhinitis.
The current allergy diagnostic reagent of house dust mites marketed in the USA is at 10,000
AU/ml. This is based on the IDEAL50 concept put forth by Turkeltaub et al, almost 3 decades
ago. Such concentration has been shown to give large degree of false positives even in the
US population.
In Thailand, it was anecdotally observed that at such concentration, sizes of positive tests
among atopic subjects were quite large and could lead to discomfort and a possible
anaphylaxis in certain allergic individuals. Moreover, up to 40% of normal individuals could
give positive reaction to this concentration.
It is therefore desirable to reexamine the appropriate concentration of diagnostic reagent
of house dust mites among the Thai population and will be the main objective of this
research.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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