Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

Rhinitis, Allergic, Nonseasonal Clinical Trial

Official title:

Individual Factors in Nasal Irritant Sensitivity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00041821
• Other study ID #: 10424-CP-001
• Status: Completed
• Phase: N/A
• First received: July 18, 2002
• Last updated: March 22, 2006
• Start date: September 2000

Study information

• Verified date: March 2006
• Source: National Institute of Environmental Health Sciences (NIEHS)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 69 Years

Eligibility

Inclusion Criteria:

• Non-smokers

• 18-69 years of age

• With or without allergic rhinitis (hay fever)

• In good general health and with no prior history of asthma

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind

Related Conditions & MeSH terms

• Rhinitis, Allergic, Nonseasonal
• Rhinitis, Allergic, Perennial

Intervention

Procedure:
• Nasal irritation thresholds and irritant provocation

Locations

Country	Name	City	State
United States	Upper Airway Biology Laboratory	Richmond	California

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Country where clinical trial is conducted

United States, 

References & Publications (2)

Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9. — View Citation

Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. — View Citation

External Links

•   Website of UCSF Upper Airway Biology Laboratory