Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Flow Mediated Dilatation (FMD)-Diameter of Artery |
FMD diameter of artery (mm, higher better) |
FMD was obtained on a single day at two different time points (after placebo and intervention) after a 5 day washout period. |
|
Primary |
Flow Mediated Dilatation-shear Rate |
|
FMD was obtained on a single day at two different time points (after placebo and intervention) after a 5 day wash out period. |
|
Primary |
Flow Mediated Dilatation- Blood Velocity |
|
FMD was obtained on a single day at two different time points (after placebo and intervention) after a 5 day wash out period. |
|
Primary |
Flow Mediated Dilatation-blood Flow |
|
FMD was obtained on a single day at two different time points (after placebo and intervention) after a 5 day wash out period. |
|
Secondary |
Oxidative Stress Measurement-MDA: Malondialdehyde |
MDA (lower better). Plasma malondialdehyde assessed by Oxis Research/Percipio Bioscience, Foster City, CA. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement-catalase (CAT) |
CAT (higher better) assessed by Cayman Chemical Company, Ann Arbor, MI. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- Protein Carbonyl |
Protein carbonyl (lower better). Plasma protein carbonyl levels assessed by Northwest Life Science Specialties, LLC Vancouver, WA. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- Ferric Reducing Ability of Plasma (FRAP) |
FRAP (higher better). FRAP assessed using the method described by Benzie and Strain. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- Superoxide Dismutase (SOD) |
SOD (higher better). SOD assessed by Cayman Chemical Company, Ann Arbor, MI. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- Interleukin 6 (IL-6) |
IL-6 (lower better), assessed by R&D Systems, Minneapolis, MN. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- Tumor Necrosis Factor Alpha (TNF-a, |
TNF-a (lower better), assessed by R&D Systems, Minneapolis, MN. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|
Secondary |
Oxidative Stress Measurement- C-reactive Protein (CRP) |
CRP (lower better). CRP assessed by R&D Systems, Minneapolis, MN. |
Oxidative stress measurements were obtained on a single day at two different time points (after placebo and intervention) after a 5-day wash out period. |
|