The Effects Of Low Intensity Training With Blood Flow Restriction In Rheumatoid Arthritis Patients

Rheumatoid Arthritis Clinical Trial

— TBFR  

Official title:

The Effects Of Low Intensity Training With Blood Flow Restriction In The Lower And Upper Limbs On Muscle Strength, Muscle Mass, Biochemical Parameters And Markers Of Systemic Inflammation In Rheumatoid Arthritis Patients: A Randomized Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05869370
• Other study ID #: 2018-0071
• Status: Recruiting
• Phase: N/A
• Start date: May 20, 2018
• Est. completion date: December 2025

Study information

• Verified date: May 2023
• Source: Federal University of Rio Grande do Sul
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Rheumatoid arthritis (RA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in physical function. On the other hand, high intensity resistance training (HIRT) are able to improve muscle strength and muscle mass in RA without affecting the disease course. However, due to the articular manifestations caused by this disease, these patients may present intolerance to HIRT. Thus, the low intensity resistance training with blood flow restriction (TBFR) may be a new training strategy for these populations. In this sense, the investigators speculate that TBFR could be beneficial in RA patients, as well as, HIRT.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 28
• Est. completion date: December 2025
• Est. primary completion date: December 2025
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 45 Years to 65 Years

Eligibility

Inclusion Criteria:

• Female;

• Rheumatoid arthritis patients;

• All individuals will undergo an ergospirometry to ensure cardiorespiratory conditions.

Exclusion Criteria:

• Fibromyalgia;

• Cardiovascular disease;

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

Intervention

Other:
• High intensity resistance training
Twelve weeks of resistance training twice a week.
• Low intensity resistance training combined with blood flow restriction
Twelve weeks of resistance training with blood flow restriction twice a week.

Locations

Country	Name	City	State
Brazil	Universidade Federal do Rio Grande do Sul - Faculdade de Medicina - Hospital de Clínicas de Porto Alegre	Porto Alegre	Rio Grande Do Sul

Sponsors (2)

Lead Sponsor	Collaborator
Federal University of Rio Grande do Sul	Hospital de Clínicas de Porto Alegre

Country where clinical trial is conducted

Brazil, 

References & Publications (1)

Dos Santos LP, Santo RCDE, Ramis TR, Portes JKS, Chakr RMDS, Xavier RM. The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis. PLoS One. 2021 Nov 10;16(11):e0259574. doi: 10.1371/journal.pone.0259574. eCollection 2021. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle strength	1 maximum repetition test.	Twelve weeks