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Januse Kinase Inhibition With Filgotinib to Silence Autoreactive B Cells in Rheumatoid Arthritis — JAKAR  

Rheumatoid Arthritis Clinical Trial

Official title:
Januse Kinase Inhibition With Filgotinib to Silence Autoreactive B Cells in Rheumatoid Arthritis

Clinical Trial Summary

To investigate the effect of filgotinib on phenotype, B cell receptor (BCR) usage and functional parameters of circulating B cells expressing ACPA in patients with ACPA-positive RA that show incomplete response to standard, medium-dose methotrexate (MTX) monotherapy.

Clinical Trial Description

B cells expressing anti citrullinated protein antibodies (ACPA) in patients with rheumatoid arthritis (RA) display an activated, proliferative phenotype. Experimental data indicate that ACPA and ACPA-expressing B cells are actively involved in driving the disease process in RA. The present study is based on the hypothesis that targeted intervention with filgotinib as a means to interfere with the activation of B cells in early, active, ACPA-positive RA can reverse the activated, proliferative phenotype of citrullinated antigen-specific B cells. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05502731
Study type Interventional
Source Leiden University Medical Center
Contact Hans Ulrich Scherer, MD PhD
Phone +31715298733
Email h.u.scherer@lumc.nl
Status Not yet recruiting
Phase Phase 4
Start date October 2022
Completion date October 2025
View Details
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