Rheumatoid Arthritis Clinical Trial
Official title:
Clinical and Dermoscopic Evaluation of Nail Findings of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis Patients and Comparison With Psoriasis Patients
Verified date | December 2021 |
Source | Bezmialem Vakif University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study evaluates the fingernail findings of the rheumatoid arthritis, spondylopathy and psoriatic arthritis patient groups with the fingernails of psoriasis patients clinically and dermatoscopically and investigates the benefit of dermoscopy in the differentiation of these patients.
Status | Completed |
Enrollment | 100 |
Est. completion date | December 20, 2021 |
Est. primary completion date | November 20, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Psoriasis confirmed by dermatologist. - Rheumatoid arthritis, ankylosing spondylitis confirmed by rheumatologist (newly diagnosed). Exclusion Criteria: - Unable to consent and understand - Patients with confirmed onychomycosis - Patients receiving biological therapy |
Country | Name | City | State |
---|---|---|---|
Turkey | Bezmialem Vakif Univesity | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Bezmialem Vakif University |
Turkey,
Wanniang N, Navya A, Pai V, Ghodge R. Comparative Study of Clinical and Dermoscopic Features in Nail Psoriasis. Indian Dermatol Online J. 2020 Jan 13;11(1):35-40. doi: 10.4103/idoj.IDOJ_51_19. eCollection 2020 Jan-Feb. — View Citation
Yorulmaz A, Artuz F. A study of dermoscopic features of nail psoriasis. Postepy Dermatol Alergol. 2017 Feb;34(1):28-35. doi: 10.5114/ada.2017.65618. Epub 2017 Feb 7. — View Citation
Zabotti A, Errichetti E, Zuliani F, Quartuccio L, Sacco S, Stinco G, De Vita S. Early Psoriatic Arthritis Versus Early Seronegative Rheumatoid Arthritis: Role of Dermoscopy Combined with Ultrasonography for Differential Diagnosis. J Rheumatol. 2018 May;45 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comparation of clinical features of nails | All of patients' fingernails will be examined clinically and visible nail findings will be noted. Many findings such as onycholysis, pitting, splinter hemorrhage, nail base vascularity, leukonychia etc. will be recorded. Also, the severity of nail involvement in psoriasis patients will be measured by the NAPSI score | six months | |
Primary | Comparation of dermoscopic features of nails | All of patients' fingernails will be examined by dermoscopy and nail findings will be noted. Also in particular, vascularization around the nail will be checked and images of all of the findings will be taken. Rheumatoid arthritis and spondylopathy patients with nail findings consistent with psoriasis will be enrolled. | six months | |
Primary | NAPSI (Psoriasis Area and Severity index) | All psoriasis patients will be scored on their nails with NAPSI (Psoriasis Area and Severity Index) scoring system.
The correlation of PASI and NAPSI will be examined. |
six months | |
Primary | PASI (Psoriasis Area and Severity Index) | Skin lesions of all psoriasis patients will be scored with the PASI (Psoriasis Area and Severity Index) system.
The correlation of PASI and NAPSI will be examined. |
six months | |
Secondary | Demographic characteristics | Demographic characteristics of patients will be compared. | through study completion, an average of 6 months |
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