Rheumatoid Arthritis Clinical Trial
Official title:
A Comparison Study of Liver Fibrosis and Its Association With Gut Microbiota in Patients With Psoriasis Vulgaris and Rheumatoid Arthritis on Methotrexate
While methotrexate (MTX) remains a treatment of choice for patients with rheumatoid arthritis
(RA), psoriasis (PsO) and psoriatic arthritis (PsA), long-term MTX use has been shown to be
associated with liver fibrosis and cirrhosis in these patients. In addition, gut dysbiosis
has been found to be associated with liver fibrosis and cirrhosis via the gut-liver axis,
underscoring the potential role of gut microbiota and bacterial translocation in the
pathogenesis of chronic liver diseases in these patients.
In this study, we aim to assess the prevalence of advanced liver fibrosis or cirrhosis among
these patients on MTX treatment compared to those without, using transient elastography. We
also aim to identify the possible risk factor(s) for advanced liver fibrosis or cirrhosis
among them. Further, we aim to characterize the difference in fecal microbiota patterns among
these three groups of patients.
Using a cross-sectional, prospective cohort design, this study will enroll approximately 600
eligible patients, including 300 patients with PsO/PsA and 300 patients with RA, to examine
the following hypotheses:
1. Patients on higher cumulative dose of MTX will have higher prevalence of advanced liver
fibrosis or cirrhosis compared to those on lower cumulative dose of MTX;
2. Patients with MTX use will have higher prevalence of advanced liver fibrosis or
cirrhosis compared to those without MTX use;
3. The fecal microbiota composition will be different between patients with and without MTX
treatment; and
4. The fecal microbiota composition will be different between patients with and without
advanced fibrosis/cirrhosis while on MTX treatment.
n/a
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