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Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

Official title:
Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid Arthritis: a Randomized Controlled Trial

Clinical Trial Summary

This study is a multicenter, randomized, double-blinded, controlled trial with two parallel arms. The aim of the study is to evaluate whether Tripterygium wilfordii Hook F combined with methotrexate (MTX) might be better than MTX alone for postmenopausal women with active rheumatoid arthritis (RA).

Clinical Trial Description

To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) and methotrexate (MTX) for postmenopausal women with active rheumatoid arthritis (RA), a multicenter, randomized controlled trial will be conducted. Three hundred postmenopausal women with active RA will be randomly allocated (1:1) to treatment with TwHF 20mg thrice daily and MTX 10 mg once a week for 24 weeks, or MTX plus dummy TwHF. The primary outcome is the percentage of participants with American College of Rheumatology 20% at week 24. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04136262
Study type Interventional
Source Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Contact Quan Jiang, M.D
Phone +8613901081632
Email doctorjq@126.com
Status Recruiting
Phase Phase 2/Phase 3
Start date November 25, 2019
Completion date December 2022
View Details
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