Rheumatoid Arthritis Clinical Trial
Official title:
Potential Role of Gum Arabic as Immunomodulator In Sudanese Rheumatoid Arthritis Patients
Gum Arabic (GA) rich dietary fiber it is a water-soluble dietary fiber derived from the
dried gummy exudates of the stems and branches of Acacia senegal, GA found to have strong
immuno modulator in vitro where it increased IL10 production showing strong
anti-inflammatory effects (19).
The aim of this study is to determine the role of gum Arabic in immunomodulation among
patients with rheumatoid arthritis.
Butyrate is short chain fatty acids representing the most important end product of colonic
bacterial aerobic fermentation of Gum Arabic , it has a potent anti-inflammatory effect and
can down regulates TNF a expression by modulating NF-kB-DNA binding activity , in addition
butyrate is known to act as histone deacetylase inhibitor in the cells.Recently, in vitro
and in vivo data indicates that HDAC inhibitors may have anti-inflammatory effect due to
their effects on cell death acting through acetylation of non-histone proteins. The possible
anti-rheumatic mechanisms of HDAC inhibitors, including growth arrest in rheumatoid
arthritis synovial fibroblasts (RASFs), suppression of pro-inflammatory cytokines,
suppressing angiogenesis as well as the protective effects on bone and cartilage against
their destruction.
The investigators expect regular intake of GA will raise serum butyrate level. The
endogenous butyrate decreases the TNF level. The latter will decrease the number of
relapsing episodes, arresting the destruction of joints and improve both survival and life
quality of rheumatoid arthritis patients.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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