A Trial With Humanized TNFα Monoclonal Antibody Injection by Single Dose and Dose Escalation in Healthy Subjects

Rheumatoid Arthritis Clinical Trial

Official title:

A Randomized, Double Blind, Placebo Controlled Trial With Humanized TNFα Monoclonal Antibody Injection by Single Dose and Dose Escalation to Explore the Tolerance, Safety and Pharmacokinetic Characteristics in Healthy Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02460393
• Other study ID #: sss07
• Status: Completed
• Phase: Phase 1
• First received: January 18, 2015
• Last updated: December 24, 2017
• Start date: May 2015
• Est. completion date: November 2015

Study information

• Verified date: December 2017
• Source: Shenyang Sunshine Pharmaceutical Co., LTD.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is a randomized, double-blind and placebo-controlled trial with healthy subjects. There are 6 Groups as follows: 5mg, 15mg, 30mg, 50mg, 75mg, 100mg, and each group includes12 people. A single subcutaneous injection will be administrated starting from the low dose group (in accordance with 5mg, 15mg, 30mg, 50mg, 75mg, 100mg administered subcutaneously). Pharmacokinetics and pharmacodynamics data will be collected; drug metabolism and pharmacokinetics characteristics will be analyzed. Drug safety and tolerance for subjects will be evaluated.

Description:

This study is a randomized, double-blind and placebo-controlled trial with healthy subjects. There are 6 Groups as follows: 5mg, 15mg, 30mg, 50mg, 75mg, 100mg, and each group includes12 people. A single subcutaneous injection will be administrated starting from the low dose group (in accordance with 5mg, 15mg, 30mg, 50mg, 75mg, 100mg administered subcutaneously). Pharmacokinetics and pharmacodynamics data will be collected; drug metabolism and pharmacokinetics characteristics will be analyzed. Drug safety and tolerance for subjects will be evaluated.

The study observed blood concentrations of the experimental drug at different time points after and before administration, TNFα before and after treatment at different time points will be observed as well.

C-T curve will be drawn with blood drug concentration (c) and time (T) in the trial. At the same time, the investigators will draw the average plasma concentration curve. Compartmental and non compartmental model will be used to analyze the pharmacokinetic parameters of subjects. It will be judged with linear or nonlinear elimination by the correlation analysis of AUC, Cmax of different doses. In the meantime, adverse events, vital signs, physical examination, laboratory examination and ECG will be evaluated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 72
• Est. completion date: November 2015
• Est. primary completion date: November 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

1. healthy adult volunteers who are voluntary to participate in clinical trials, and signed the informed consent

2. aged 18-45 years, the same batch of subjects age difference is less than or equal to 10 years of age

3. subjects with qualified physical examination within 7 days before the trial, body mass index (BMI) from19 to 24 ,and the same batch of subjects are with the similar weight

4. the basic indicators of heart, liver, kidney and blood examination are in the normal range.

Exclusion Criteria:

1. subjects are during the acute or chronic infection period, or have a previous history of active tuberculosis

2. subjects are with the history of diseases of the central nervous system, cardiovascular system, kidney, liver (specific indexes of liver function), digestive system ,respiratory system or metabolic system or suffered from other significant disease

3. subjects as allergic constitution after inquiry, suspected or confirmed or have a history of drug, food allergy , or subjects with a clear history of allergies and / or allergic to the humanized TNF alpha monoclonal antibody or the ingredient of humanized TNF alpha monoclonal antibody , or serum immunoglobulin E (IgE) examination was abnormal

4. subjects are included in other clinical trials of other drugs 3 months before being enrolled in this clinical trial, or candidates used drugs known to have damage to the main organs within 3 months before this trial;

5. candidates with blood donation history 3 months before being enrolled

6. Prescription and non prescription drugs were administrated Within 2 weeks before inclusion

7. ALT or AST > 1.5N (the upper limit of normal), Cr>N (the upper limit of normal);

8. leukocyte absolute value less than 3.50 × 109/L or > 9.50× 109/L, neutrophil absolute value less than 1.8× 109/L, platelet counts less than 100 × 109/L, hemoglobin is less than 100g/L

9. hepatitis B surface antigen (HbsAg), hepatitis C antibody (HCV-Ab), acquired immunodeficiency syndrome (Anti-HIV) antibody and anti Treponema pallidum antibody (TP-Ab) are positive subjects

10. candidates with positive tuberculin skin test with 5 unit dose tuberculin , the size of 48-72 hour scleroma greater than 5 mm

11. subjects with positive anti nuclear antibodies (ANA, ds-DNA, ENA)

12. subjects with positive resistantance antibody

13. subjects had a history of mental illness

14. subjects who are pregnant, lactating women or a planning pregnant within 3 months

15. subjects with the history of orthostatic hypotension

16. with drug or drug abuse history after inquiry

17. daily smoking more than 5 cigarettes or the same amount of tobacco after inquiry

18. subjects drink more than 28 units of alcohol after inquiry, or alcohol breath test are positive within 24 hours before the acceptance of the tested drugs

19. There is a family history of cancer

20. Significantly abnormal values in clinical appeared during the screening

21. subjects cannot understand, exchangeand cooperate enough, and cannot guarantee the researchers according to the scheme

22. researchers don't think it is right to participate in the research with other reasons.

Related Conditions & MeSH terms

• Arthritis, Rheumatoid
• Rheumatoid Arthritis

Intervention

Drug:
• Humanized TNFa monoclonal antibody
Subcutaneous injection of different doses for healthy people Subcutaneous injection of different doses in healthy people

Other:
• placebo
Subcutaneous injection of different doses for healthy people

Locations

Country	Name	City	State
China	Peking University People's Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Shenyang Sunshine Pharmaceutical Co., LTD.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	AUC	AUC	28 days
Primary	Cmax	Cmax	28 days
Primary	Cmin	Cmin	28 days
Primary	Tmax	Tmax	28 days
Secondary	Serum creatinine and AST and ALT	Serum creatinine and AST and ALT	28 days
Secondary	or any other adverse events	or any other adverse events	28 days