Clinical Trial Details
— Status: Terminated
Administrative data
| NCT number |
NCT02441920 |
| Other study ID # |
RG_09-196 |
| Secondary ID |
|
| Status |
Terminated |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
November 2010 |
| Est. completion date |
November 2012 |
Study information
| Verified date |
February 2017 |
| Source |
University of Birmingham |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Periodontitis is a highly prevalent chronic inflammatory disease that is characterized by
loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss.
Results from clinical and epidemiological studies have suggested that periodontitis and tooth
loss are more prevalent in individuals with rheumatoid arthritis (RA). There is evidence to
suggest that periodontitis could indeed be a causal factor in the initiation and maintenance
of the autoimmune inflammatory response that occurs in RA. If so, chronic periodontitis might
represent an important modifiable risk factor for RA. However, to date longitudinal studies
on the effect of periodontitis on disease progression in RA are lacking. The aim of the
present study is to assess the periodontal status of patients enrolled in an established
longitudinal cohort of RA patients. These data will then be analysed to evaluate whether or
not periodontal inflammation is related to parameters of rheumatoid arthritis.
Description:
Chronic periodontitis is arguably the most prevalent chronic inflammatory disease in humans.
The defining feature of periodontitis is chronic inflammation of the tooth-supporting
tissues, leading to the progressive destruction of periodontal ligament and alveolar bone.
Periodontitis is a very common disease, affecting over 30% of adults aged 65 years or above
in the UK. Results from a growing number of clinical studies point towards a potential
association between chronic periodontitis and systemic rheumatic diseases- in particular,
rheumatoid arthritis (RA). If proven, such an association would be very important from a
clinical and public health perspective for several reasons. First, there are several
processes through which chronic periodontitis might be part of a causal pathway in the
pathogenesis and/or disease activity status of RA. Given the high prevalence of chronic
periodontitis, a large proportion of the incidence and/or morbidity of RA could be
attributable to chronic periodontitis, if causality was confirmed.
Importantly, chronic periodontitis would represent a modifiable risk factor, as effective
treatments for this disease are available. Second, chronic periodontitis would contribute to
morbidity in patients with RA even if the association was noncausal. Periodontitis is a
leading cause of tooth loss in adults, which can have important clinical consequences,
including impaired nutritional status and quality of life. Furthermore, chronic periodontitis
is associated with an increased incidence of coronary heart disease and stroke, and emerging
evidence indicates that this association might, in part, be causal, and thus periodontitis
may contribute to the increased cardiovascular morbidity and mortality in RA.
