Rheumatoid Arthritis Clinical Trial
Official title:
Duration of Immune Response to Influenza Vaccination in Patients With Rheumatoid Arthritis Receiving Treatment With Biologic Agents
The main objective is to evaluate the strength and duration of immune response after influenza vaccination in patients with Rheumatoid Arthritis (RA) receiving treatment with biological agents as compared to a group healthy controls who do not have RA. Influenza vaccine titers will be drawn 3 times: at Baseline(prior to vaccination), 4-6 weeks post vaccination, and 5-6 months post vaccination. Influenza vaccination will be done at the baseline visit after the baseline blood draw.
Aims:
- Evaluate the strength and duration of immune response after influenza vaccination in
patients with Rheumatoid Arthritis (RA) receiving treatment with biological agents.
- Evaluate for predictors of immune response such as age, gender, disease duration, type
of the biological agent(s) used, duration of the treatment, and type of treatment in
the past.
- Assess the efficacy of vaccine response in this population by recording proportion of
patients who contracted influenza illness despite vaccination. The result of the study
may provide more information regarding which situations inadequate immune response by
strength or duration would most likely to be expected. This may help lay some
groundwork for future studies looking at the use of booster vaccinations in this
population
;
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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