The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

Official title: The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis, a Controlled and Randomized Trial

Status Completed

Clinical Trial Summary

The purpose of this study is to access the effect (week 12/week 24) of puerarin injection on carotid intima-media thickness (CIMT) in rheumatoid arthritis (RA) patients despite routine anti-rheumatic treatment.

Clinical Trial Description

• Controlled, randomized trial

• RA patients under routine anti-rheumatic care were randomized to receive the treatment with or without 400 mg puerarin injection

• Assessments were made at entry, 12 and 24 weeks

• The overall sample size was assessed before the enrollment

• Randomization was performed using concealed random allocation method

• The collected data was processed and assessed by two reviewers

• All the measurement and analysis procedures concerning CIMT were performed by a single ultra sonographer and a single reader, who were blinded to patient profiles and group assignment

• The reproducibility of the ultrasonographic method was test before the trial ;

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

• NCT number: NCT02254655
• Study type: Interventional
• Source: Chengdu PLA General Hospital
• Status: Completed
• Phase: Phase 2
• Start date: November 2013
• Completion date: November 2017