Genetics and Mechanisms of Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

— RASGENAS  

Official title:

Rheumatoid Arthritis Susceptibility Genes in Austrian and Slovak Population

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01788098
• Other study ID #: RASGENAS
• Secondary ID: ATMOS N00024
• Status: Completed
• Phase: N/A
• First received: February 3, 2013
• Last updated: February 7, 2013
• Start date: October 2009
• Est. completion date: December 2012

Study information

• Verified date: February 2013
• Source: Slovak Academy of Sciences
• Contact: n/a
• Is FDA regulated: No
• Health authority: Slovak Republic: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 790
• Est. completion date: December 2012
• Est. primary completion date: June 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• rheumatoid arthritis or healthy

Exclusion Criteria:

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Genetic Association Studies
• Leukocytes, Mononuclear
• Rheumatoid Arthritis

Locations

Country	Name	City	State
Slovakia	Slovak Academy of Sciences, Center for Molecular Medicine	Bratislava

Sponsors (1)

Lead Sponsor	Collaborator
Slovak Academy of Sciences

Country where clinical trial is conducted

Slovakia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Genetic association	Association of selected single nucleotide polymorphisms with rheumatoid arthritis.	1 day	No
Secondary	Peripheral blood mononuclear cells reactivity	Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.	1 day	No