Rheumatoid Arthritis Clinical Trial
Official title:
In Vivo Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and Antigen Presenting (APC) Cells in Rheumatoid Arthritis
This proposal will test the hypothesis that Orencia affects apoptosis and apoptosis related genes/biomarkers in vivo in rheumatoid arthritis (RA) patients.
Orencia may regulate apoptosis and apoptosis related genes in vivo in rheumatoid arthritis
(RA) patient's cells. To date, no studies have been performed to evaluate the effect of
Orencia on apoptosis in RA patients.
Primary: To determine the effect of Abatacept in the apoptosis of T cells, B cells and
antigen presenting cells (APC) in RA patients at baseline, 3 months and 6 months.
Secondary: To evaluate the association between the changes in apoptosis to changes in
disease activity measures (DAS28/ESR) over 6 months of treatment with subcutaneous injection
of abatacept.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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