Rheumatoid Arthritis Clinical Trial
— MAINTAINOfficial title:
Retention Rates of Adalimumab, Etanercept and Infliximab as First and Second-Line Biotherapy in Patients With Rheumatoid Arthritis in Daily Practice
To compare retention rates of adalimumab, etanercept and infliximab as first-line biotherapy in rheumatoid arthritis (RA), to determine causes of discontinuation, retention-associated factors, and retention rates of possible second-line tumor necrosis factor α inhibitors (TNFi).
Status | Completed |
Enrollment | 780 |
Est. completion date | September 2011 |
Est. primary completion date | September 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - RA defined by the 1987 ACR criteria [18] - first TNFa inhibitor prescribed in the previously mentioned period - TNFa inhibitor prescribed as first-line biotherapy - undergone at least one evaluation in the center after treatment initiation Exclusion Criteria: - previously received another biotherapy - TNFa inhibitor was prescribed in an RCT - refused to participate |
Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Pfizer | scientific steering committee of KOL in rheumatology |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Compare retention rates of adalimumab, etanercept and infliximab administered as first-line biologic therapy in RA | 2 years | No | |
Secondary | Compare retention rates of TNFa inhibitor monoclonal antibodies (adalimumab and infliximab) and the soluble receptor (etanercept) | 4 years | No | |
Secondary | Causes of discontinuing these treatments | 4 years | Yes | |
Secondary | Determine the factors associated with better retention of the first TNFa inhibitors | 4 years | Yes | |
Secondary | Compare retention rates of possible second-line TNFa inhibitors | 4 years | Yes |
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