Rheumatoid Arthritis Clinical Trial
Official title:
Exercise-induced Improvements of Inflammatory Status in Patients With Rheumatoid Arthritis - Improvements of Cardiovascular Risk Factors and Quality of Life
The primary aim of the study is to investigate if 10 weeks of high intensity interval training improve inflammatory status in patients with rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many
tissues and organs, but principally attacks synovial joints. Although the cause of
rheumatoid arthritis is unknown, autoimmunity plays a role in both the chronicity and
progression, and RA is considered as a systemic autoimmune disease.
Due to chronic inflammatory status, RA-patients are at higher risk of developing
cardiovascular disease (CVD) compared to the general population. Accumulating evidence
indicates that regular physical activity has beneficial effects on RA. The mechanisms behind
exercise-induce improvements are none the less unclear and more research is needed to better
understand the beneficial effects of exercise training in this patient group.
Recently, promising results from gene expression studies of blood cells have revealed
unexplored fields of biomarker discovery and gene expression profiling of disease. Due to
easy accessible and minimally invasive sample collection, gene expression profiling of whole
blood might turn out to be a promising tool in molecular diagnostics and clinical medicine.
To our knowledge, whole-genome transcriptional changes have not previously been studied in
RA-patients undergoing a high-intensity exercise program.
Hypothesis: Ten weeks of high intensity interval training improves the inflammatory status,
quality of life, and known risk factors for cardiovascular diseases.
In addition to measure traditionally inflammatory markers in the blood, whole genome
analysis will be made.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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