Rheumatoid Arthritis Clinical Trial
Official title:
A 2 Year Prospective Multicentre Randomised Controlled Trial Comparing Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.
The Combinatietherapie Bij Reumatoide Artritis (CoBRA) trial was a milestone in the
development of the present treatment paradigm for Rheumatoid Arthritis (RA). This study
introduced the principle of fast remission induction by means of a combination of standard
Disease Modifying AntiRheumatic Drugs (DMARDs) and a step down bridge therapy with high dose
glucocorticoids in early Rheumatoid Arthritis.
The purpose of the present study is to compare different combinations of traditional DMARDs
and glucocorticoids, based on the original CoBRA protocol, for treatment of early Rheumatoid
Arthritis.
Besides the efficacy and effectiveness of these strategies, patient centered outcomes and
potential implementation problems of such treatment strategies are evaluated.
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