Rheumatoid Arthritis Clinical Trial
Verified date | July 2009 |
Source | National Chung Hsing University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Institutional Review Board |
Study type | Observational |
Polymorphisms occur in several genes encoding key enzymes in the folate pathway may affect
drug metabolism in patients with rheumatoid arthritis. Whether these genetic variations
contribute to differential responses to antifolate drug in patients with rheumatoid
arthritis (RA) remains to be investigated in the Taiwanese population.
Objective. The goal of the present study is to investigate the interactions between genetic
variations in folate genes and the efficacy/side effects of anti-folate disease-modifying
antirheumatic drug in Taiwan.
DESIGN. A cross-sectional study involving 100 patients with RA were enrolled from TCVGH.
Genotypes in methylenetetrahydrofolate reductase (MTHFR677C>T), tandem repeat polymorphism
in thymidylate synthase enhancer region (TSER) and folylpoly-gamma-glutamate synthetase
(FPGS1901T>C) were determined by RFLP or pyrosequencing.
Status | Completed |
Enrollment | 0 |
Est. completion date | February 2007 |
Est. primary completion date | February 2007 |
Accepts healthy volunteers | |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Male/female age >18 - Clinical diagnosis of Rheumatoid Arthritis Exclusion Criteria: - Must not be pregnant/breastfeeding - Other conditions may lead to exclusion from the trial (e.g. Diabetes mellitis, malignant melanoma, cardiac conduction disorders, hepatic/renal insufficiency. |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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National Chung Hsing University | Taichung Veterans General Hospital |
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