Rheumatoid Arthritis Clinical Trial
Official title:
A Phase 2, 12-Week, Randomized, Placebo-Controlled Study to Evaluate the Antiinflammatory Effects of VX-702 When Administered Concomitantly With Methotrexate
The purpose of this study is to assess the safety and effects of VX-702 in subjects with moderate to severe rheumatoid arthritis and who are taking the drug methotrexate.
Status | Completed |
Enrollment | 120 |
Est. completion date | July 2007 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Adult patients 18 to 75 years of age with active RA - Must have been taking MTX for at least 6 months - No concurrent DMARD treatment (other than a stable dose of MTX) Exclusion Criteria: - Planned major surgery (e.g., joint replacement) within the duration of the treatment period of the study - Treated with intra-articular injections of corticosteroids within 28 days prior to Day 1 |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Bulgaria | Call For Information | Dimitrovgrad | |
Bulgaria | Call For Information | Pleven | |
Bulgaria | Call For Information | Sofia | |
Bulgaria | Call For Information | Veliko Tarnovo | |
Croatia | Call For Information | Osijek | |
Croatia | Call For Information | Zagreb | |
Former Serbia and Montenegro | Call For Information | Belgrade | |
Former Serbia and Montenegro | Call For Information | Niska Banja | |
Former Serbia and Montenegro | Call For Information | Zemun | |
Poland | Call For Information | Bytom | |
Poland | Call For Information | Krakow | |
Poland | Call for Information | Torun | |
Poland | Call For Information | Zyrardow | |
Russian Federation | Call For Information | Novosibirsk | |
Russian Federation | Call For Information | Saratov | |
Russian Federation | Call For Information | St. Petersburg | |
Slovenia | Call For Information | Ljubljana |
Lead Sponsor | Collaborator |
---|---|
Vertex Pharmaceuticals Incorporated |
Bulgaria, Croatia, Former Serbia and Montenegro, Poland, Russian Federation, Slovenia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To evaluate the effects of VX-702 administered with concomitant methotrexate (MTX), and MTX alone | |||
Secondary | To evaluate the safety and tolerability of VX-702 administered with concomitant MTX, and MTX alone |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04226131 -
MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
|
N/A | |
Completed |
NCT04171414 -
A Study to Evaluate Usability of Subcutaneous Auto-injector of CT-P17 in Patients With Active Rheumatoid Arthritis
|
Phase 3 | |
Completed |
NCT02833350 -
Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)
|
Phase 2 | |
Completed |
NCT04255134 -
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)
|
Phase 4 | |
Recruiting |
NCT05615246 -
Exactech Humeral Reconstruction Prosthesis of Shoulder Arthroplasty PMCF (HRP)
|
||
Completed |
NCT03248518 -
Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases
|
N/A | |
Completed |
NCT03514355 -
MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
|
N/A | |
Recruiting |
NCT06005220 -
SBD121, a Synbiotic Medical Food for RA Management
|
N/A | |
Recruiting |
NCT05451615 -
Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis
|
Phase 3 | |
Completed |
NCT05054920 -
Eccentric Versus Concentric Exercises for Rotator Cuff Tendinopathy in Patients With Rheumatoid Arthritis
|
N/A | |
Completed |
NCT02037737 -
Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting
|
N/A | |
Recruiting |
NCT04079374 -
Comparative Efficacy, Safety and Immunogenicity Study of Etanercept and Enbrel
|
Phase 3 | |
Completed |
NCT02504268 -
Effects of Abatacept in Patients With Early Rheumatoid Arthritis
|
Phase 3 | |
Recruiting |
NCT05496855 -
Remote Care in People With Rheumatoid Arthritis
|
N/A | |
Completed |
NCT05051943 -
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
|
||
Recruiting |
NCT06031415 -
Study of GS-0272 in Participants With Rheumatoid Arthritis
|
Phase 1 | |
Recruiting |
NCT06103773 -
A Study of Single and Multiple Oral Doses of TollB-001
|
Phase 1 | |
Completed |
NCT05999266 -
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
|
||
Recruiting |
NCT05302934 -
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
|
||
Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 |