Rheumatoid Arthritis Clinical Trial
Official title:
Specimen Procurement for Individuals With Pulmonary Fibrosis Associated With Rheumatoid Arthritis
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and
fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid
arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown.
Researchers hope to improve their understanding of the disease process involved in PF and RA
by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or
autopsy from patients with these conditions.
The purpose of this study is to collect specimens from rheumatoid arthritis patients with and
without pulmonary fibrosis as well as patients with pulmonary fibrosis without associated
diseases or cause (idiopathic pulmonary fibrosis).
The etiology of pulmonary fibrosis in individuals with rheumatoid arthritis is unknown. Analysis of blood and specimens procured by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from patients with this disorder will contribute to our understanding of the pathogenetic mechanisms of pulmonary fibrosis in rheumatoid arthritis. The purpose of this protocol is to obtain blood and specimens by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from rheumatoid arthritis patients with and without pulmonary fibrosis, individuals with idiopathic pulmonary fibrosis, and healthy research volunteers. ;
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