Renal Failure Clinical Trial
Official title:
Myoglobin Reduction by High Cut-off (HCO) Continuous Veno- Venous Hemodialysis (CVVHD) in Patients With Rhabdomyolysis and an Increased Risk for Acute Kidney Injury
A high cut-off dialyzer (septeX) is tested for the removal of myoglobin which is not efficiently removed by standard high flux dialysis membranes. Hypothesis: The high cut-off dialyzer (septeX) can remove 2-fold more efficiently myoglobin from the circulation of Rhabdomyolysis patients as by conventional treatment with standard high flux dialyzer.
Excess myoglobin in the circulation is a causative pathogenetic factor of rhabdomyolysis
associated with acute kidney injury (AKI). The rapid elimination of myoglobin by standard
dialysis membranes is limited to its molecular weight of 17.8kDa, although some removal can
be achieved when a convective therapy is applied.
Significant clearance for myoglobin has been reported for high flux membranes from < 8
mL/min (5) up to 22 mL/h (CVVH) (10) and for high cut-off (HCO) membranes a mean clearance
rate of 36.2 mL/min in HD mode (7) and 39.2 mL/h in CVVH mode (5). The use of high cut-off
(HCO) continuous veno- venous hemodialysis (CVVHD) may constitute a novel therapeutic
strategy for effectively reduction of myoglobin in the patient's serum to ameliorate the
course of AKI.
Previously, a case study of the removal of myoglobin by HCO-CVVH in one single patient with
severe rhabdomyolysis was published.
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