The Association of Genetic Polymorphisms With Statin-Induced Myopathy.

Status Recruiting

Clinical Trial Summary

To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of statins-induced myopathy.

Clinical Trial Description

Statins are widely prescribed for the patients with hypercholesterolemia.

Though their efficacy in preventing cardiovascular events has been shown by a large number of clinical trials, myotoxic side effects including myopathy or even more severe,rhabdomyolysis are associated with the use of statins.

Because the incidence of myopathy is various among individuals,polymorphism in genes is supposed to be the main factor.

Due to single nucleotide polymorphism in related genes,level of uptake, clearance and metabolism of statins can be seriously different among individuals resulting in various occurrence of myopathy.

Therefore, analytical study in association between SNP of statins-related genes and the incidence of myopathy is such a critical research which can be applied into clinical fields. ;

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00549029
Study type	Observational
Source	National Taiwan University Hospital
Contact	Yen-Hui Chen, PhD
Phone	886-2-2312-3456
Email	tcyhchen@ntu.edu.tw
Status	Recruiting
Phase	N/A
Start date	August 2007
Completion date	January 2008

View Details

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