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NCT00427063 Clinical Trial

Heredity of Retinal Vessel Tortuosity

Retinopathy of Prematurity Clinical Trial

Official title:
Heredity of Retinal Vessel Tortuosity - A Twin Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00427063
Other study ID # Danish Twin Registry 1998
Secondary ID
Status Completed
Phase N/A
First received January 25, 2007
Last updated January 25, 2007
Start date January 1998
Est. completion date December 1998

Study information
Verified date January 2007
Source Glostrup University Hospital, Copenhagen
Contact n/a
Is FDA regulated No
Health authority Denmark: Ethics Committee
Study type Observational

Clinical Trial Summary

The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Description:

All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Recruitment information / eligibility
Status Completed
Enrollment 218
Est. completion date December 1998
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 20 Years to 46 Years
Eligibility Inclusion Criteria:

- Samesex twin pairs of self-assessed good health

Exclusion Criteria:

- Diabetes mellitus

- Hypertension

- Thyroid disease

- Cataract or other opacities of the refractive media

- Missing fundus photographs

Study Design

Observational Model: Defined Population, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Denmark Department of Ophthalmology Glostrup Hospital Glostrup Copenhagen County

Sponsors (2)
Lead Sponsor Collaborator
Glostrup University Hospital, Copenhagen Juvenile Diabetes Research Foundation

Country where clinical trial is conducted

Denmark, 

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