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Retinitis clinical trials

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NCT ID: NCT05176717 Terminated - Clinical trials for Retinitis Pigmentosa

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Start date: December 15, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy safety and tolerability of QR-421a administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene with early to moderate vision loss.

NCT ID: NCT05085964 Terminated - Clinical trials for Retinitis Pigmentosa

An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa

HELIA
Start date: September 16, 2021
Phase: Phase 2
Study type: Interventional

PQ-421a-002 (Helia) is an open-label, extension study to evaluate the safety, tolerability and efficacy of QR 421a (ultevursen) administered via intravitreal (IVT) injection in one or both eyes, in subjects ≥ 12 years of age with RP due to mutations in exon 13 of the USH2A gene, for an anticipated period of 24 months, or until provision of continued treatment by other means is available, provided the subject's benefit-risk determination remains positive.

NCT ID: NCT04295304 Terminated - Clinical trials for Retinitis Pigmentosa

NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases

NR
Start date: January 17, 2020
Phase: N/A
Study type: Interventional

The study objective is to demonstrate safety of the NR 600 System, and to evaluate the performance of the device in restoring visual activity of daily living in subjects with retinal degenerative diseases and severe visual impairment

NCT ID: NCT02926092 Terminated - Clinical trials for Retinitis Pigmentosa

Observational Natural History Study of Autosomal Dominant Retinitis Pigmentosa (adRP)

Start date: March 13, 2017
Phase:
Study type: Observational

The purpose of this study is to gain an understanding of how adRP progresses over time in patients with misfolded rod opsin mutations.

NCT ID: NCT01860092 Terminated - Clinical trials for Retinitis Pigmentosa

New Enrollment Post-Approval Study of the Argus® II Retinal Prosthesis System

Start date: January 2014
Phase:
Study type: Observational

This post-approval study is being implemented to monitor the use of Argus II System in a larger US population than available within pre-approval studies. An attempt will be made to include all eligible and willing subjects implanted with Argus II System in the United States.

NCT ID: NCT01786395 Terminated - Clinical trials for Retinitis Pigmentosa

Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa

Start date: March 2013
Phase: Phase 3
Study type: Interventional

This study is a multicenter trial performed in Japan, consisting of a comparative study period and a continuous administration period. Effect of 0.15% UF-021 eye drops on improvement in central retinal sensitivity with HFA will be verified in 52 weeks comparative study period by a placebo-controlled, double-masked study in patients with retinitis pigmentosa. The safety of same eye drops will also be examined in 52 weeks continuous administration period, in all the patients who completed the comparative study period.

NCT ID: NCT01505062 Terminated - Clinical trials for Retinitis Pigmentosa

Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B

Start date: March 26, 2012
Phase: Phase 1/Phase 2
Study type: Interventional

To evaluate the safety and tolerability of ascending doses of subretinal injections of SAR421869 in participants with Usher syndrome type 1B. To evaluate for possible biological activity of SAR421869.

NCT ID: NCT01490827 Terminated - Clinical trials for Retinitis Pigmentosa

Argus® II Retinal Prosthesis System Post-Market Surveillance Study

Start date: November 2011
Phase:
Study type: Observational

This post-market surveillance study is conducted in the European Economic Area where Argus II has been CE certified for use in outer retinal degeneration patients.

NCT ID: NCT01415453 Terminated - Clinical trials for Retinitis Pigmentosa

Evoked Retinal Response

Start date: July 2011
Phase: N/A
Study type: Interventional

Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye). RP causes the breakdown of photoreceptor cells (cells in the retina that detect light). Photoreceptor cells capture and process light helping us to see. As these cells breakdown and die, people experience progressive vision loss. There is no known cure for retinitis pigmentosa. The investigators have observed that short pulses of focused ultrasound can cause perception of light when directed to spots on the retinal surface. The investigators propose to conduct a study to determine if pulsed ultrasound will stimulate the perception of light in the absence of functional photoreceptors in people with RP

NCT ID: NCT00550498 Terminated - Retinitis Clinical Trials

Stem Cell Transplantation in Ocular Lesions of Behcet's Disease

Start date: December 2007
Phase: Phase 1
Study type: Interventional

The purpose of this study is to find if autologous stem cell transplantation can stop the progression of intractable eye lesions of Behcet's Disease or even to improve it.