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Retinal Perforations clinical trials

View clinical trials related to Retinal Perforations.

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NCT ID: NCT03332758 Completed - Retinal Detachment Clinical Trials

Inflammasomes in Cell Death in FTMH, ERM, and RRD

Start date: September 8, 2017
Phase:
Study type: Observational

Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane. The investigators are collecting vitreous and subretinal fluid samples from patients with these conditions and evaluating activity of the inflammasome pathway with established assays.

NCT ID: NCT03174639 Completed - Retinal Detachment Clinical Trials

High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps

Start date: March 11, 2016
Phase: N/A
Study type: Interventional

From July 2015 to December 2015, clinical record of 8 consecutive cases of macular hole with retinal detachment in high myopia treated with combined inverted and free ILM flap insertion into the hole were retrospectively reviewed. The anatomical and function outcomes were assessed.

NCT ID: NCT03020459 Completed - Surgery Clinical Trials

Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

To compare the morphologic and functional outcomes of internal limiting membrane peeling-reposition versus peeling in idiopathic macular holes

NCT ID: NCT02946372 Completed - Clinical trials for Retinal Perforations

Evaluation of a New Surgical Technique for Macular Hole Which Was Not Closed After a Previous Surgery

ILMT
Start date: November 2016
Phase: N/A
Study type: Interventional

Macular hole is an infrequent retinal pathology (2 to 4/1000) which most often affects people aged over 60, and twice common in women than men. The vast majority of cases are idiopathic. Without treatment, the macular hole evolves through a series of stages until the extension of the diameter (up to 500 microns and higher values). With a fully developed macular hole, patients complain of metamorphopsia and decreased visual acuity. This pathology has clearly benefited from advances in microsurgery and better understanding of its pathophysiology. Macular hole treatment has evolved to include small-gauge pars plana vitrectomy with or without internal limiting membrane (ILM) peeling and placement of intraocular gas tamponade. The postoperative closure rate is close to 80%, but strongly depends on the initial characteristics of the hole, its diameter remaining the main prognostic factor. Thus for macular holes <400 microns, the closure rate is close to 92% dropping to 56% for macular holes above 400 microns. In case of surgical failure, one or more reoperations can be proposed, but with a lower closure rate. The quest for a surgical technique presenting a greater success rate is a common goal to all retinologists. Here the investigators propose a new surgical technique, derived from the FLAP method, and consisting of an inner limiting membrane transposition. The objective of this study is to evaluate the feasibility of a new surgical technique for the treatment of macular holes already operated but without macular hole closure, allowing these patients a new therapeutic alternative. The success of this technique will be confirmed by detecting postoperatively the presence of the transposed internal limiting membrane into the foveal region.

NCT ID: NCT02930369 Completed - Macular Hole Clinical Trials

Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery

Start date: June 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).

NCT ID: NCT02896972 Completed - Clinical trials for Macular Hole Retinal Detachment

Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes

Start date: April 2012
Phase: N/A
Study type: Interventional

To evaluate efficacy of vitrectomy with inverted internal limiting membrane (ILM) flap technique for macular hole retinal detachment (MHRD) in highly myopic eyes, and to demonstrate postoperative clinical course of MHRD after inverted ILM flap technique using swept-source optical coherence tomography (OCT)

NCT ID: NCT02895594 Completed - Clinical trials for Idiopathic Macular Hole

Outcome of Surgery for Idiopathic Macular Holes

TROMAC
Start date: January 2012
Phase: N/A
Study type: Observational

Retrospective medical chart review of patients undergoing surgical repair of idiopathic macular hole

NCT ID: NCT02894424 Completed - Clinical trials for Macular Hole Surgery

Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery

MICROCOL
Start date: February 23, 2017
Phase:
Study type: Observational

The idiopathic macular hole, age-related disease, is a major cause of vision loss and affects at least two persons in 1000 after 40 years. This hole causes an acute decline linked to a central scotoma. The only treatment is surgical. The surgery involves removing the posterior hyaloid (vitreous base) to relieve the tensile forces. To be sure the removed is complete and to facilitate the closure of the hole, a peeling of the internal limiting, the outermost layer of the retina, is often suggested. The inner limiting membrane (ILM), transparent and adherent to the retina, is colored with vital dyes to facilitate its removal. After closure of the macular hole, the central scotoma disappears but a diffuse and asymptomatic loss of pericentral sensitivity is often described. This sensitivity decrease could be induced by the dyes used during surgery. This effect has not been studied clinically for recent dyes (Membrane Blue Dual®, Brilliant Blue®, Acid Violet®) at the concentrations used, but is known in electrophysiology at higher concentrations, at least on the isolated retina models. It would be interesting to search for a decrease in retinal peri-foveal postoperative sensitivity after surgery of macular holes, performed with the usual dyes. Only microperimetry can observe this decrease in retinal sensitivity. This is a noninvasive technique that explores the macular visual field. It is performed without iris dilatation and allows an automatic exploration ensuring rapid and accurate analysis of retinal sensitivity.

NCT ID: NCT02691429 Completed - Clinical trials for Diabetic Retinopathy

Applicability of the Acai Fruit (Euterpe Oleracea) Dye for Chromovitrectomy in Humans

Start date: February 2016
Phase: N/A
Study type: Interventional

Our research group tested the toxicity of different dye concentrations extracted from the acai fruit using a rabbit model. The dye extracted from the acai fruit in concentrations of 10% and 25% was found to be safe for vitreoretinal surgery. This initial research represented the landmark research for testing this alternative vital dye in a clinical research in humans. The aim of the present clinical trial in humans will be to test the applicability of the acai dye in the identification of the posterior hyaloid and ILM during vitreoretinal surgery in humans.

NCT ID: NCT02650739 Completed - Clinical trials for Macular Hole Surgery

Optical Coherence Tomography-based Positioning for Macular Hole Surgery

Start date: May 2013
Phase: N/A
Study type: Observational

The efficacy of macular hole (MH) surgery with the halting of prone positioning by monitoring the MH closure in the swept source optical coherence tomographic (SS-OCT) images was compared with the surgery by the surgeon's decision. The macular hole closure and visual outcome were compared.