Retinal Disease Clinical Trial
Official title:
Changes in Retinal Nerve Fiber Layer Thickness Detected by Optical Coherence Tomography in Diabetic Retinopathy After Panretinal Photocoagulation
Panretinal photocoagulation reduces the risk of visual loss by 50% in patients with diabetic
retinopathy. It is recognized that laser expansion into the retina may be associated with
photoreceptor loss, retinal pigment epithelial hypertrophy and visual field loss.
Panretinal photocoagulation can cause alteration in retinal vascular permeability therefore,
retinal thickness may be increased including retinal nerve fiber layer. On the contrary, it
can damage retinal cells including ganglion cells, which may decrease the retinal nerve fiber
layer thickness in the latter follow up period.
Peripapillary retinal nerve fiber layer can be measured by optical coherence tomography which
is a non-invasive technique for obtaining high resolution cross sectional images of a tissue.
Pre laser assessment:
- Assessment of medical and family history
- Refraction and best corrected visual acuity
- Anterior segment examination using binocular slit lamp bi-microscopy.
- Posterior segment examination.
- OCT scan of peripapillary area
Post laser assessment ( at 1,3 and 6 months):
- Refraction and best corrected visual acuity.
- Anterior segment examination using binocular slit lamp bi-microscopy.
- Posterior segment examination.
- OCT scan of peripapillary area.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04956237 -
Retinal Surgery With or Without Anesthesiologist, Comparison of Surgeon and Patient's Comfort
|
||
| Recruiting |
NCT01432847 -
Cell Collection to Study Eye Diseases
|
||
| Active, not recruiting |
NCT04130841 -
Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery
|
N/A | |
| Recruiting |
NCT03713268 -
Intraoperative OCT Guidance of Intraocular Surgery II
|
||
| Active, not recruiting |
NCT03872479 -
Single Ascending Dose Study in Participants With LCA10
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT04636307 -
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
|
||
| Recruiting |
NCT02921568 -
Side-by-Side Comparison of P200TE and Spectral OCT/SLO on Diseased Eyes
|
N/A | |
| Completed |
NCT02315170 -
Assessment of Novel Intraocular Injection Guide
|
N/A | |
| Completed |
NCT00069199 -
Optical Coherence Tomography Comparative Study
|
N/A | |
| Withdrawn |
NCT03603990 -
Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema
|
N/A | |
| Active, not recruiting |
NCT04123626 -
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
|
Phase 1/Phase 2 | |
| Withdrawn |
NCT02445001 -
Erythrocyte Ghost Mediated Retinal Diagnosis
|
N/A | |
| Completed |
NCT01468337 -
Topical Interferon Gamma-1b for Central Serous Chorioretinopathy
|
Phase 1/Phase 2 | |
| Completed |
NCT01227993 -
Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
|
Phase 1/Phase 2 | |
| Completed |
NCT00792259 -
Topcon 3D OCT-1000 Optical Coherence Tomography System
|
||
| Completed |
NCT00035906 -
Research Study in Patients With Persistent Macular Edema
|
Phase 2 | |
| Recruiting |
NCT05158699 -
Effectiveness of Periocular Drug Injection in CATaract Surgery
|
Phase 3 | |
| Terminated |
NCT04110015 -
Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis
|
||
| Recruiting |
NCT03592017 -
Performance of Long-wavelength Autofluorescence Imaging
|
N/A | |
| Recruiting |
NCT03823092 -
Polarization Perception in Health and Disease. Testing a New Sight Test
|