Retinal Disease Clinical Trial
Official title:
Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis)
Verified date | July 25, 2008 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study offers evaluation and treatment for patients with inflammatory eye diseases, such
as uveitis. The protocol is not designed to test new treatments; rather, patients will
receive current standard of care treatments. The purpose of the study is twofold: 1) to allow
National Eye Institute physicians to increase their knowledge of inflammatory eye conditions
and identify new avenues of possible research in this area; and 2) to establish a pool of
patients who may be eligible for new studies as they are developed. (Participants in this
protocol will not be required to join a new study; the decision will be voluntary.)
Children and adults with uveitis and other inflammatory eye diseases may be eligible for this
study. Candidates will be screened with a medical history, brief physical examination,
thorough eye examination and blood tests. The eye examination includes measurements of visual
acuity (ability to see the vision chart), eye pressure and dilation of the pupils to examine
the lens and retina (back part of the eye). Patients may also undergo the following
procedures:
1. Fundus photography - Special photographs of the inside of the eye to help evaluate the
status of the retina and evaluate changes that may occur in the future. From 2 to 20
pictures may be taken, depending on the eye condition. The camera flashes a bright light
into the eye for each picture.
2. Fluorescein angiography - Procedure to evaluate the eye's blood vessels. A yellow dye
injected into an arm vein travels to the blood vessels in the eyes. Pictures of the
retina are taken using a camera that flashes a blue light into the eye. The pictures
show if any dye has leaked from the vessels into the retina, indicating possible blood
vessel abnormality.
Participants will be followed at least 3 years. Follow-up visits are scheduled according to
the standard of care for the individual patient's eye problem. Vision will be checked at each
visit, and some of the screening tests described above may be repeated to follow the progress
of disease and evaluate the response to treatment.
Status | Completed |
Enrollment | 300 |
Est. completion date | July 25, 2008 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 4 Years and older |
Eligibility |
- INCLUSION CRITERIA: Patients are initially screened for NEI protocols under the NEI screening protocol or from the closeout of another protocol. Some of these patients will have a uveitic or other intraocular inflammatory condition that NEI staff wishes to follow and treat. Such patients can the be enrolled in this evaluation and treatment protocol. Each study participant must have the ability to understand and sign an informed consent form. EXCLUSION CRITERIA: Patients will be excluded from this study if they are unable or unwilling to give informed consent or the are unwilling to be followed and treated at the NEI clinical center for at least the next 3 years. |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Eye Institute (NEI) |
United States,
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04956237 -
Retinal Surgery With or Without Anesthesiologist, Comparison of Surgeon and Patient's Comfort
|
||
Recruiting |
NCT01432847 -
Cell Collection to Study Eye Diseases
|
||
Active, not recruiting |
NCT04130841 -
Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery
|
N/A | |
Recruiting |
NCT03713268 -
Intraoperative OCT Guidance of Intraocular Surgery II
|
||
Active, not recruiting |
NCT03872479 -
Single Ascending Dose Study in Participants With LCA10
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT04636307 -
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
|
||
Not yet recruiting |
NCT06451068 -
Peripheral Retina Robotically Aligned OCT Study
|
N/A | |
Recruiting |
NCT02921568 -
Side-by-Side Comparison of P200TE and Spectral OCT/SLO on Diseased Eyes
|
N/A | |
Completed |
NCT02315170 -
Assessment of Novel Intraocular Injection Guide
|
N/A | |
Completed |
NCT00069199 -
Optical Coherence Tomography Comparative Study
|
N/A | |
Withdrawn |
NCT03603990 -
Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema
|
N/A | |
Active, not recruiting |
NCT04123626 -
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
|
Phase 1/Phase 2 | |
Withdrawn |
NCT02445001 -
Erythrocyte Ghost Mediated Retinal Diagnosis
|
N/A | |
Completed |
NCT01468337 -
Topical Interferon Gamma-1b for Central Serous Chorioretinopathy
|
Phase 1/Phase 2 | |
Completed |
NCT01227993 -
Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
|
Phase 1/Phase 2 | |
Completed |
NCT00792259 -
Topcon 3D OCT-1000 Optical Coherence Tomography System
|
||
Completed |
NCT00035906 -
Research Study in Patients With Persistent Macular Edema
|
Phase 2 | |
Recruiting |
NCT05158699 -
Effectiveness of Periocular Drug Injection in CATaract Surgery
|
Phase 3 | |
Terminated |
NCT04110015 -
Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis
|
||
Recruiting |
NCT03592017 -
Performance of Long-wavelength Autofluorescence Imaging
|
N/A |