Correlation Between OCT and mFERG Findings With VA After Vitrectomy Surgery for Retinal Detachment

Retinal Detachment Clinical Trial

Official title:

Correlation Between Optical Coherence Tomography and Multifocal Electroretinogram Findings With Visual Acuity After Vitrectomy Surgery for Retinal Detachment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05993208
• Other study ID #: CBOCT&MFERG&VA-VRD
• Status: Completed
• Start date: January 1, 2023
• Est. completion date: November 15, 2023

Study information

• Verified date: August 2023
• Source: New Valley University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity after vitrectomy surgery for Retinal detachment.

Description:

Although the anatomical success rate of vitreoretinal surgery has improved over the last decade, visual results remain compromised? Patients with macula-off retinal detachments (RDs) can have poor visual recovery, specific color vision defects, or metamorphopsia postoperatively despite successful retinal reattachment. In these cases, subtle changes in the foveal structure may be causing visual disturbances that can be difficult to identify during standard clinical examinations such as slit lamp biomicroscopy or binocular indirect ophthalmoscopy .reported a possible association between incomplete visual recovery and the presence of residual subretinal fluid (SRF) postoperatively.

Optical coherence tomography (OCT) is a non-invasive technique that provides information about the morphology of the retina, and especially of the macular area in vivo. Some studies support the idea that OCT determines structural changes in the macula that are correlated with subjective visual function, including visual acuity (VA) in patients with vitrectomy for retinal detachment. Additionally, multifocal electroretinogram (m fERG) evaluation can be helpful in assessing macular function in post-vitrectomy. However, to date, there are relatively few reports concerning the combined use of OCT and m fERG for the correlation between retinal morphology and function of the macula in patients with vitrectomy for retinal detachment surgery. The purpose of our study is to determine whether a significant correlation exists between the amplitude of m fERG, visual acuity, and the morphological OCT changes by in the macula after vitrectomy for retinal detachment

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: November 15, 2023
• Est. primary completion date: May 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• patients with successful vitrectomy for retinal detachment.

Exclusion Criteria:

• The patients who had vitrectomy for reasons other than retinal detachment surgery

• Patients who had done scleral buckle surgery

• Patients with media opacity are prevented from doing retina imaging.

• Failed or recurrent vitrectomy surgery

Related Conditions & MeSH terms

• Dissociative Disorders
• Retinal Detachment

Intervention

Diagnostic Test:
• optical coherence tomography,multifocal electroretinogram. VA measurment
retinal photography

Locations

Country	Name	City	State
Egypt	New Vally University	Sohag

Sponsors (2)

Lead Sponsor	Collaborator
New Valley University	Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	CMT,BCVAand mf-ERG were recoreded in 40 eyes of 40 patintes with vitrectomy for retinal detchament surgery .	Each 10 um increase in central (CMT) associated by how increase decimal in Best corrected visual acuity and by how nV/deg2 increase multifocal electroretinogram in these eyes .	6 months
Primary	BCVA(best corrected visual acuity)	Best corrected Visual acuity measurement using Snellen's Acuity Chart and will be expressed as decimal notation	6 Month
Primary	CMT(central macualr thikness ) um	centeral macualr thikness mesurment using using optical chorent tomgraphgy	6 month
Primary	mf-ERG amplituide nV/deg2	multifocal electroretinogram amplituide mesurement using mf-ERG machine	6 month