Clinical Trials Logo

Clinical Trial Summary

Photoreceptor apoptosis is the basis for permanent visual loss in a number of retinal disorders including age-related macular degeneration (AMD) and retinal detachment (RD). Thus, despite tremendous advances in vitreoretinal surgery and management of rhegmatogenous RD leading to a primary reattachment rate over 95%, some patients show poor visual recovery because of photoreceptor apoptosis. Physiologically, microglial cells (resident macrophages) are present only in the inner retina. The subretinal space, located between the retinal pigment epithelium (RPE) and the photoreceptor outer segments (POS), is devoid of all mononuclear phagocytes and form a zone of immune privilege. In AMD, several studies showed a strong association between subretinal mononuclear phagocytes infiltration and advanced forms of AMD. Experimental work in mice suggest that this infiltration plays an important role in the pathogenesis of this condition by producing inflammatory cytokines. RD-induced photoreceptor apoptosis might result from similar mechanisms. The aim of this study is to determine the cytokine profile in vitreous samples from patients with RD and to compare it with those from control patients with macular hole.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03318588
Study type Observational
Source Central Hospital, Nancy, France
Contact
Status Completed
Phase
Start date November 15, 2017
Completion date October 11, 2018

See also
  Status Clinical Trial Phase
Completed NCT03332758 - Inflammasomes in Cell Death in FTMH, ERM, and RRD
Completed NCT03660384 - Silicone Oil Versus Gas in PDR Patients Undergoing Vitrectomy N/A
Recruiting NCT03713268 - Intraoperative OCT Guidance of Intraocular Surgery II
Completed NCT04535622 - Efficacy of Exercise Program for Facedown Posture-related Pain After Retinal Surgery N/A
Recruiting NCT05863312 - REtinal Detachment Outcomes Study N/A
Recruiting NCT05561569 - Air Versus Gas Tamponade in Primary Retinal Detachment N/A
Not yet recruiting NCT05538156 - Internal Limiting Membrane Peeling in Retinal Detachment Surgery N/A
Completed NCT03046719 - Subconjunctiva Bupivacaine as Analgesia in Intravitreal Silicone Oil Removal N/A
Recruiting NCT01261533 - Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment Phase 1
Terminated NCT02068625 - Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment Phase 4
Completed NCT00000140 - The Silicone Study Phase 3
Recruiting NCT05543018 - Effect of Intraocular Tamponade on Visual Perception N/A
Not yet recruiting NCT04518696 - Suprachoroidal Buckling for the Management of Rhegmatogenous Retinal Detachment N/A
Completed NCT03321253 - Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification N/A
Completed NCT06166914 - Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment N/A
Enrolling by invitation NCT05566626 - Retinal Oxygenation Estimation Trial With Mantis Photonics Hyperspectral Camera N/A
Not yet recruiting NCT03631108 - Feasibility Study and Preliminary Application Study on Iris OCTA
Recruiting NCT02201706 - Multi-electrocoagulation Retinectomy for Retinal Re-detachment in Silicone Oil Filled Eye N/A
Completed NCT03218371 - Scleral Self-indentation Chandelier-assisted Peripheral Vitrectomy Under Air Rhegmatogenous Retinal Detachment. N/A
Completed NCT00000154 - Diabetic Retinopathy Vitrectomy Study (DRVS) Phase 3