Retinal Degeneration Clinical Trial
Official title:
A Multi-Center Study of Reading Rehabilitation in Macular Disease
Verified date | February 2015 |
Source | VA Office of Research and Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
The purpose of this study is to measure the effectiveness of a newly-designed oculomotor training program for patients with macular disease, including age-related macular degeneration.
Status | Completed |
Enrollment | 36 |
Est. completion date | September 2012 |
Est. primary completion date | September 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients with a diagnosis of macular disease, such as age-related macular degeneration - An established preferred retinal locus - Visual acuity of less than or equal to 20/70 and greater than or equal to 20/400 (in the better eye) Exclusion Criteria: - Those with other major ophthalmologic and neurologic disease - choroidal neovascularization ("wet" AMD) - moderate to severe media opacities, and cognitive impairment |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor)
Country | Name | City | State |
---|---|---|---|
United States | Jesse Brown VAMC (WestSide Division) | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sentence Reading | To assess reading performance, after each training module (1-3), two lines of text were presented at the center of the monitor. Each subject was seated with his or her forehead on a head rest at a viewing distance of 40cm. The subject read each sentence aloud and indicated whether it made sense by responding true or false. Reading speed was calculated using an algorithm similar to that used for the MNRead test. The number of words read correctly was divided by the time required to read the sentence to yield a measure of reading speed in words per minute (wpm). Sentences were displayed at sizes of 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6 log units above the subject's letter acuity threshold. Five sentences were presented at each font size. We used 105 different sentences so that no sentence was repeated for any subject. Average speed of reading (log wpm) was plotted as a function of font size (logMAR). | Pre-training, 6 weeks, 12 weeks, 18 weeks | No |
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