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Restless Legs Syndrome clinical trials

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NCT ID: NCT04610827 Terminated - Sleep Disorder Clinical Trials

Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder

Start date: November 16, 2020
Phase: Phase 4
Study type: Interventional

The purpose of this research study is to see if the level of serum ferritin differs based on how often oral iron (in the form of ferrous sulfate) is given to children with restless leg syndrome/periodic limb movement disorder.

NCT ID: NCT03992196 Terminated - Clinical trials for Restless Legs Syndrome

A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome

Start date: December 3, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the long-term safety, tolerability and the long-term efficacy of rotigotine treatment in adolescents with idiopathic Restless Legs Syndrome (RLS).

NCT ID: NCT03852771 Terminated - Clinical trials for Restless Legs Syndrome

REST Study (CompRESsion Therapy for RLS)

REST
Start date: March 12, 2019
Phase: N/A
Study type: Interventional

This study in patients with restless leg syndrome (RLS) will evaluate the use of Cirvo™ therapy for the treatment of this disorder when applied to both legs.

NCT ID: NCT03817554 Terminated - Clinical trials for Restless Legs Syndrome

Pramipexole for Restless Leg Syndrome in Peritoneal Dialysis Patients

Start date: July 1, 2019
Phase: Phase 4
Study type: Interventional

A randomized, double-blind controlled Study from a single center to evaluate the effect and safety of pramipexole on peritoneal dialysis patients with restless legs syndrome

NCT ID: NCT03728933 Terminated - Clinical trials for Restless Legs Syndrome

A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause

Start date: December 20, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the efficacy of rotigotine against placebo in adolescent subjects with idiopathic Restless Legs Syndrome (RLS) over a 12-week maintenance period and to investigate the safety and tolerability of rotigotine in adolescent subjects with idiopathic RLS.

NCT ID: NCT03708237 Terminated - Clinical trials for End Stage Renal Disease

Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD

Start date: February 19, 2019
Phase: Phase 2
Study type: Interventional

Restless legs syndrome (RLS) is a neurologic disorder characterized by 1) an urge to move the legs, 2) uncomfortable sensations in the legs, 3) symptoms that are often worse the evening or when at rest , and 4) may be temporarily relieved by physical activity. The overall prevalence of RLS in the general population is estimated to be around 10%, however, it is significantly in the end stage kidney disease (ESKD) population is significantly higher (approximately 30%). Studies have shown that RLS has a substantial negative impact on both the physical and the mental health dimensions of quality of life (QOL), such as depression, anxiety, pain, fatigue and sleep disorder. While non-pharmacological treatments should be considered for all patients, pharmacological management of RLS is indicated when the affects patient's sleep or quality of life. Gabapentin and dopamine agonists such as ropinirole are usually the first choices in treating RSL. Although these medications are also used in patients with renal impairment, few studies provide treatment data for the hemodialysis population. Treatment recommendations for this population are largely based on data obtained in the general population. This study aims to evaluate effectiveness of ropinirole and gabapentin for the treatment of restless legs syndrome in patients on maintenance hemodialysis.

NCT ID: NCT03345953 Terminated - Clinical trials for Restless Legs Syndrome

Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome

P13-04
Start date: February 6, 2018
Phase: Phase 2
Study type: Interventional

This is a Group Sequential Test multicenter, randomized, double blind, placebo controlled phase II proof of concept trial with parallel groups to evaluate the efficacy and the safety of BP1.4979 15mg BID compared to placebo in RLS patients during 2 weeks double blind treatment.

NCT ID: NCT02826681 Terminated - Clinical trials for Restless Legs Syndrome (RLS)

Randomized, Placebo-controlled Trial of Ferric Carboxymaltose in RLS Patients With Iron-deficiency Anemia

Start date: July 10, 2017
Phase: Phase 2
Study type: Interventional

Treatment Phase I and II Primary Objective: To evaluate the efficacy and safety of FCM (750 mg dose x 2) for treatment of Restless Legs Syndrome (RLS) in patients with iron-deficiency anemia (IDA). Long-Term Extension Phase III Primary Objective: To evaluate the duration of effect of prior FCM treatment and to determine the effectiveness of further iron repletion with FCM when RLS symptoms worsen or reoccur.

NCT ID: NCT02117076 Terminated - Clinical trials for Restless Leg Syndrome

Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome

Start date: April 2014
Phase: Phase 4
Study type: Interventional

The study will compare the safety, effectiveness and tolerability of gabapentin (Neurontin) versus gabapentin enacarbil (Horizant) as treatment restless leg syndrome.

NCT ID: NCT01192503 Terminated - Clinical trials for Restless Legs Syndrome

Safety and Efficacy of Rasagiline in Restless Legs Syndrome

RAS-RLS
Start date: September 2010
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to find out if rasagiline improves RLS symptoms. We also want to make sure rasagiline is safe to give people with RLS.