Response to Hyperoxia Clinical Trial
Official title:
Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter
- Due to the increased risk of brain damage, continuous monitoring of the cerebral
oxygenation is interesting. The investigators will evaluate the capability of the INVOS
Oximeter to detect induced changes in the cerebral regional saturation.
- The purpose of the study is to investigate our hypothesis that cerebral
vasoconstriction after oxygen exposure is prolonged in preterm infants compared to term
infants.
Preterm infants are at increased risk of brain damage compared with term infants, and
cerebral hypoxia is considered to have an important role. The preterm infants are at
increased risk of respiratory distress, episodes with low oxygenation, mechanical
ventilation, risk of hypocapnia and labile or low blood pressure. These conditions can
affect the microcirculation and hence the oxygenation of the brain. Hyperoxia is also a
point of interest, since high levels of oxygen can cause vasoconstriction.
The investigators will examine the normal physiological cerebral response to exposure of
oxygen in a group of preterm infants with a gestational age (GA) of 32-37 weeks and a group
of term infants.
The investigators will do dynamic research with continuously monitoring of the cerebral
oxygenation using the INVOS® Cerebral/Somatic Oximeter (Near InfraRed Spectroscopy (NIRS)).
Reproducibility is examined by repeated measurements.
There will be no follow-up.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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