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Respiratory Tract Diseases clinical trials

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NCT ID: NCT03849625 Completed - Clinical trials for Aspirin-exacerbated Respiratory Disease

Characteristics of Patients Diagnosed With NSAID Sensitivity in Thailand

Start date: May 1, 2015
Phase:
Study type: Observational

Study clinical characteristics and phenotypes of patients diagnosed with NSAID sensitivity in Thailand

NCT ID: NCT03848156 Completed - Polyp Sinus Clinical Trials

Characterisation of Nasal Polyps in Patients With and Without Aspirin-exacerbated Respiratory Disease

Start date: February 12, 2019
Phase:
Study type: Observational

Prevalence of aspirin-exacerbated respiratory disease (AERD) is 16% amongst patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). The mechanisms underlying the observed dysregulation of pro and anti-inflammatory pathways in AERD are still not fully understood. To address this and also to identify potential factors characterizing the disease the investigators plan to prospectively collect blood samples, nasal secretions as well as nasal biopsies from allergic, non-allergic and AERD patients suffering from CRSwNP. Initially, polyps of aforementioned patients will be subjected to RNA sequencing analysis using microarray technology. Once distinct factors are identified in nasal polyp tissue, their presence will be assessed in nasal secretions and serum of the respective patients to investigate their potential role as biomarkers. Furthermore presence of these parameters will be confirmed in situ in biopsies by confocal microscopy. Knowledge about factors differently upregulated in polyp tissue from AERD may contribute to a better understanding of the underlying mechanism of the disease.

NCT ID: NCT03843541 Completed - Clinical trials for Respiratory Tract Diseases

A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions

Start date: June 25, 2019
Phase: Phase 3
Study type: Interventional

This is a phase 3, multicenter, randomized, rater- and patient-blind, placebo- and active-controlled, 3-arm parallel group clinical trial. Patients will be randomized to N-acetylcysteine (NAC) or ambroxol or placebo in a 1:1:1 ratio. A total of approximately 333 patients in China will be randomized. The total study duration will be approximately 8 months including the enrolment period of approximately 7 months and the patient participation duration of 1 month or 4 weeks. Each patient will undergo a screening period of up to 1 week, a 1-week treatment period and a 2-week follow-up period. This study will be conducted in approximately 15-25 sites in China.

NCT ID: NCT03799666 Completed - Clinical trials for Chronic Respiratory Disease

(Re)Vitalizing Pulmonary Rehabilitation for Patients With Chronic Respiratory Diseases

3R
Start date: January 7, 2019
Phase: N/A
Study type: Interventional

3R aims to increase the access of patients with chronic respiratory diseases (CRD) to pulmonary rehabilitation (PR) in Portugal. The main goals of 3R are: i) design and implement an innovative community-based PR programme; ii) assess the cost-benefit of the community-based PR programme; iii) disseminate and perform knowledge transfer about PR across the country. PR is an evidence-based intervention for the management of CRD and offering PR has been defined as a priority by national/international organizations. However, in Portugal PR is practically inexistent (<1% of "candidate" patients have access). Currently, PR programmes are hospital-based and directed to patients with advanced disease. One of the recommendations to enhance the implementation of PR is the development on novel models of programme delivery. It is hypothesised that community-based programs, direct to patients at all grades of the disease, and involving all stakeholders (health professionals, patients, society, policy makers) may turn PR more accessible. The plan is to implement community-based PR programs in 4 primary care centres of 2 ACES of the centre region of Portugal and assess the impact of such intervention in several domains using surrogate and patient-/family-centered outcomes. A cost-benefit analysis will be performed on acute exacerbations and healthcare utilization. Dissemination will include one conference, activities with the community, courses and an online PR toolkit. Four schools of 2 polytechnics, 2 city councils, the Health Regional Administration-Centre (ARS-Centro) and all respiratory professional and civic national associations are partners.

NCT ID: NCT03776773 Completed - Allergic Rhinitis Clinical Trials

Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

POLLAR
Start date: April 8, 2019
Phase: N/A
Study type: Interventional

It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated. Sleep is associated to physical and mental health, alterations in sleep could explain the link between AR and work productivity diminution, impairment in daily activities or emotional problems. However, interactions between air pollution, sleep and allergic diseases are insufficiently understood. The main objective of this study is to determine the impact of pollution and pollens on sleep parameters.

NCT ID: NCT03764319 Completed - Lung Diseases Clinical Trials

Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO

Start date: November 6, 2018
Phase: N/A
Study type: Interventional

The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is a rescue treatment for patients with severe ARDS. Mechanical ventilator settings in patients with severe ARDS during ECMO therapy are not clearly defined at the moment.

NCT ID: NCT03750110 Completed - Heart Diseases Clinical Trials

Yorkshire Enhanced Stop Smoking Study

YESS
Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Lung cancer rates are higher in Yorkshire than the rest of the UK, and this is due to higher rates of smoking. Deaths from lung cancer can be reduced using regular lung scans (screening) and by helping people stop smoking. As well as detecting cancers, scans can also show evidence of damage to lungs (emphysema) and heart arteries (calcification). This study will test whether people can be encouraged to quit smoking by giving them pictures from their own scans showing possible lung and heart damage, along with information about how stopping smoking reduces their risk of cancer and heart attacks.

NCT ID: NCT03748472 Completed - Respiratory Disease Clinical Trials

The Effect of Feeding Length on the Oxygenation Instability Among Premature Infants

Start date: May 29, 2019
Phase: N/A
Study type: Interventional

SpO2 instability is in the nature of premature infants. Hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. Different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. Premature infants are fed via an NG/OG tube. Feeding length might influence the oxygenation instability among premature infants therefore the aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when are fed over 30 min vs over 2 hours, as documented by SpO2 histograms.

NCT ID: NCT03744169 Completed - Respiratory Failure Clinical Trials

Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.

Start date: December 1, 2018
Phase:
Study type: Observational

The purpose of this study is to determine the utility of point-of-care lung ultrasound (POC-LUS) in identifying the etiology of acute respiratory failure in pediatric patients admitted to the pediatric intensive care unit.

NCT ID: NCT03739112 Completed - Clinical trials for Respiratory Tract Infections

Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly

Start date: September 18, 2018
Phase: Phase 3
Study type: Interventional

This Phase 3 study was intended to assess the relative efficacy of the Quadrivalent VLP Influenza Vaccine during the 2018-2019 influenza season compared to a licensed vaccine in elderly adults 65 years of age and older. One dose of VLP Influenza Vaccine (30 μg/strain) or of Comparator (15 μg/strain) was to be administered to 12,738 participants.