Acute Health Effects of Traffic-Related Air Pollution Exposure

Status Active, not recruiting

Clinical Trial Summary

This study aims to assess the effects of acute exposure to traffic-related air pollution and the underlying mechanisms.

Clinical Trial Description

The investigators will conduct a randomized, crossover trial among 72 healthy young adults in Shanghai, China. The eligible participants will be randomly divided into 2 groups (36 volunteers per group). During the first stage, participants will be requested to take one walking task (from 13:00 to 17:30). The exposed group will walk along a busy road and be exposed to traffic-related air pollution, while the control group will walk in a traffic-free park. During the first 3 hours, all participants will rest for 30 minutes after each 15-minute walking. From 16:00, participants will stop walking and rest for 1.5 hours. Then both groups will enter a 2-week washout period. In the second stage, there will also be one walking task (from 13:00 to 17:30). The two groups will exchange their walking sites and repeat the previous trial. Physical examinations will be performed both before and after each walking task. Besides, we will ask volunteers to stay in school during the two days before walking. Health examinations include symptoms questionnaires, blood pressure tests, Holter monitoring, and spirometry. We plan to collect blood, urine, oropharyngeal swabs, and exhaled breath condensate before exposure, about one hour after exposure, and next morning. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04153539
Study type	Interventional
Source	Fudan University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	October 9, 2019
Completion date	December 31, 2022

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