Bronchiolitis Clinical Trial
Official title:
Cough Assist in RSV-bronchiolitis
RSV bronchiolitis in children is still associated with significant morbidity and mortality.
RSV infection results in increased mucus production, edema and inflammation at the lower
airways and impaired mucociliary clearance. Infants and children under the age of 1 year are
particularly vulnerable to complications such as atelectasis and secondary bacterial
infection. These children often need non-invasive or invasive ventilation. Atelectasis is
common in these children because of smaller airways and decreased cough strength. There is
still much uncertainty about the treatment of RSV. Treatment consists primarily of supportive
therapy such as tube feeding and additional respiratory support if necessary. There is also
limited evidence about the use of nebulizers with beta-agonists and/or hypertonic saline.
The cough assist is a mechanical in- and exsufflator used primarily in patients with
neuromuscular diseases to augment cough capacity. In these patients, it was demonstrated that
the use of assisted cough resulted in a significant decrease in the number of respiratory
infections. Moreover, there is evidence that when used in the case of an acute respiratory
deterioration such a massive atelectasis, the atelectasis can be corrected and intubation can
be avoided. The aim of this study is to investigate if the use of the CoughAssist device in
children with RSV bronchiolitis is associated with a better respiratory outcome.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04989114 -
Nasal Bubble Continuous Positive Airway Pressure in Reducing Respiratory Distress in Children With Bronchiolitis
|
N/A | |
Recruiting |
NCT06016244 -
Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial
|
N/A | |
Not yet recruiting |
NCT05902702 -
Isotonic Saline for Children With Bronchiolitis
|
N/A | |
Recruiting |
NCT02366715 -
Treatment Of Bronchiolitis With Heated Humidified High Flow Nasal Cannula - Prospective And Retrospective Research
|
Phase 3 | |
Terminated |
NCT02219334 -
Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study
|
N/A | |
Recruiting |
NCT01944995 -
Work of Breathing in Nasal CPAP Versus High Flow Nasal Prong in Infants With Severe Acute Bronchiolitis
|
N/A | |
Terminated |
NCT02834819 -
Nebulized 3% Hypertonic Saline vs. Standard of Care in Patients With Bronchiolitis
|
N/A | |
Not yet recruiting |
NCT01414322 -
Documentation of Continuous Wheeze and Cough Dynamics in Pediatric ER SOB Patients
|
N/A | |
Completed |
NCT00369759 -
An Epidemiological Study to Evaluate the RSV-Associated Lower Respiratory Track in Infections in Infants
|
N/A | |
Completed |
NCT00347880 -
Atrial and Brain Natriuretic Peptides in Bronchiolitis
|
Phase 1 | |
Recruiting |
NCT05548036 -
A Feasibility RCT of Aerobika Verses ACBT in People With COPD
|
N/A | |
Active, not recruiting |
NCT04302207 -
The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study
|
N/A | |
Completed |
NCT02858531 -
Predictive Tracking of Patient Flow in the Emergency Services During the Virus Winter Epidemics
|
||
Withdrawn |
NCT05994183 -
The Bronchiolitis in Hospitalized Infants Study
|
Early Phase 1 | |
Terminated |
NCT03614507 -
Automation Oxygen Flow Titration in Spontaneously Breathing Infants
|
N/A | |
Completed |
NCT02856165 -
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
|
N/A | |
Recruiting |
NCT05909566 -
Respiratory Support and Treatment for Efficient and Cost-Effective Care
|
N/A | |
Recruiting |
NCT04437641 -
Impact of Pediatrician Intervention on the Smoking Habits of Parents of Sick Children
|
||
Not yet recruiting |
NCT06083077 -
Chest and Abdominal Wall Strapping in Infant With Bronchiolitis
|
N/A | |
Recruiting |
NCT02708147 -
Impact of Respiratory Physiotherapy in Children With Bronchiolitis in the First Two Years of Life
|
N/A |