Indirect Measurement of Respiratory Quotient in Unipulmonary Ventilation.

Respiratory Quotient Measurement Clinical Trial

Official title:

Validation of the Respiratory Quotient Measurement Measured Indirectly in Unipulmonary Ventilation (UNIQ Study)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03751605
• Other study ID #: PI2018_843_0047
• Status: Completed
• Start date: November 1, 2018
• Est. completion date: February 1, 2023

Study information

• Verified date: February 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The measurement of VO2 and VCO2 makes it possible to calculate the respiratory quotient (RQ) (VCO2 / VO2) which is a reflection of human energy metabolism and therefore of anaerobiosis. A study has been conducted in our department to demonstrate the ability of the indirectly measured respiratory quotient (RQ) from the inspired and exhaled breath analysis of the anesthetic respirator to predict the onset of anaerobic metabolism and postoperative complications in the operating room.

Unipulmonary ventilation is the rule in thoracic surgery: it improves surgical exposure and protects the operated lung.

However, no study has examined the impact of these mechanisms on the indirect measurement of RQ in unipulmonary ventilation. The main objective of our work is to validate indirect RQ measurement during unipulmonary ventilation. The secondary objective was to assess the predictability of postoperative complications of indirect QR.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: February 1, 2023
• Est. primary completion date: May 1, 2019
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age>18 years old

• Adults admitted to the operating room for thoracic surgery requiring unipulmonary ventilation

Exclusion Criteria:

• Cardiac surgery

• Laparoscopy

• Preoperative oxygen therapy

Related Conditions & MeSH terms

• Respiratory Quotient Measurement

Intervention

Procedure:
• unipulmonary ventilation
observational study based on the computation of respiratory quotient in patient cohort treated by unipulmonary ventilation in routine thoracic surgery

Locations

Country	Name	City	State
France	CHU Amiens	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Indirect respiratory quotient		during surgery
Secondary	occurrence of at least one post-operative complication	the aim is to predict the occurrence of at least one complication with the use of indirect respiratory quotient	through study completion, an average of 6 months